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Research progress on the roles and inhibitors of deubiquitinase USP28 in tumors
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Xing LI1, Bo-ya ZHANG1, Li-ting LU1, Yan WANG1, Shuai WEN1, Yong-jun ZANG2, *, Xiang-ming XU1, *, Yi MOU1, *
Acta Pharmaceutica Sinica | 2024, 59(11) : 2941 - 2952
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Acta Pharmaceutica Sinica | 2024, 59(11): 2941-2952
Research progress on the roles and inhibitors of deubiquitinase USP28 in tumors
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Xing LI1, Bo-ya ZHANG1, Li-ting LU1, Yan WANG1, Shuai WEN1, Yong-jun ZANG2, *, Xiang-ming XU1, *, Yi MOU1, *
Affiliations
  • 1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China
  • 2. Department of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China
Published: 2024-11-12 doi: 10.16438/j.0513-4870.2024-0098
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The deubiquitinases (DUBs), as the crucial peptidohydrolases in the ubiquitin system, can reverse and strictly regulate ubiquitination and play key roles in various biological processes, including the regulation of protein stability, cell signal transduction. Ubiquitin-specific protease 28 (USP28) involves multiple cancer-related signaling pathways by enhancing the stability of various cancer-related proteins, and is closely associated with the progression of colorectal, breast cancer, lung carcinomas, and pancreatic cancer. USP28 has been considered as a promising drug target in anticancer therapy, and the development of USP28 inhibitors has made some progress. In this article, we review the structure of USP28 and its interaction with substrates, discuss the research progress of USP28 in cancers and summarize the development of USP28 inhibitors.

deubiquitylating enzyme  /  ubiquitin-specific protease 28  /  cancer  /  inhibitor  /  ubiquitination
Xing LI, Bo-ya ZHANG, Li-ting LU, Yan WANG, Shuai WEN, Yong-jun ZANG, Xiang-ming XU, Yi MOU. Research progress on the roles and inhibitors of deubiquitinase USP28 in tumors[J]. Acta Pharmaceutica Sinica, 2024 , 59 (11) : 2941 -2952 . DOI: 10.16438/j.0513-4870.2024-0098
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doi: 10.16438/j.0513-4870.2024-0098
  • Receive Date：2024-01-30
  • Online Date：2025-11-24
  • Published：2024-11-12
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  • Received：2024-01-30
  • Revised：2024-05-13
Affiliations
    1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China
    2. Department of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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