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Two new diphenyl ethers from the whole plant of Canscora lucidissima
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Meng-yu ZHANG1, 2, Jiao LIU2, 3, Chang LIU1, 2, Tao ZHANG2, *, Zhong-mei ZOU1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(12) : 3335 - 3341
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Acta Pharmaceutica Sinica | 2024, 59(12): 3335-3341
Two new diphenyl ethers from the whole plant of Canscora lucidissima
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Meng-yu ZHANG1, 2, Jiao LIU2, 3, Chang LIU1, 2, Tao ZHANG2, *, Zhong-mei ZOU1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
  • 3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0648
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Twelve compounds were isolated and purified from 95% ethanol extract of the whole plant of C. lucidissima by silica gel column chromatography, MCI column chromatography and ODS column chromatography, polyamide column chromatography, Sephadex LH-20 column chromatography, combined with semi-preparative HPLC methods. Based on the physicochemical properties and spectral data (UV, IR, MS, NMR), the structures of the isolates were identified as canlucdiphenyl ether A (1), canlucdiphenyl ether B (2), canlucbenzophenone A (3), (-)-pinoresinol (4), 3-hydroxybenzoic acid (5), 1, 3, 8-trihydroxy-6-hydroxymethylanthraquinone (6), dihydrokaempferol (7), 6, 7-dihydroxycoumarin (8), 4-hydroxy-3, 5-dimethoxybenzoic acid (9), 4-hydroxy-3, 5-dimethoxycinnamic acid (10), 2-hydroxy-3-methoxybenzoic acid (11), (-)-syringaresinol (12). Among them, compounds 1 and 2 are two new diphenyl ether and 3 is a new natural product. Compound 8 exhibited some anti-inflammatory activity by inhibiting the lipopolysaccharide-induced NO production in RAW264.7 cells.

Gentiaceae  /  Canscora lucidissima  /  chemical constituent  /  diphenyl ether  /  anti-inflammatory effect
Meng-yu ZHANG, Jiao LIU, Chang LIU, Tao ZHANG, Zhong-mei ZOU. Two new diphenyl ethers from the whole plant of Canscora lucidissima[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3335 -3341 . DOI: 10.16438/j.0513-4870.2024-0648
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Year 2024 volume 59 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2024-0648
  • Receive Date：2024-07-10
  • Online Date：2025-11-24
  • Published：2024-12-12
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History
  • Received：2024-07-10
  • Revised：2024-09-02
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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