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Study on secondary metabolites of an endophytic fungi Alternaria tenuissima Pas85
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Ya-ling JIANG1, 2, Wei-ping LI1, 3, Cheng-cheng HU2, Xue-ru GUO2, Yang WANG2, Xin-xin ZHANG2, Ke LI1, Wen-yuan LI1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(12) : 3330 - 3334
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Acta Pharmaceutica Sinica | 2024, 59(12): 3330-3334
Study on secondary metabolites of an endophytic fungi Alternaria tenuissima Pas85
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Ya-ling JIANG1, 2, Wei-ping LI1, 3, Cheng-cheng HU2, Xue-ru GUO2, Yang WANG2, Xin-xin ZHANG2, Ke LI1, Wen-yuan LI1, 2, *
Affiliations
  • 1. Henan Engineering Research Center of Water Environment and Health, Zhengzhou University of Industrial Technology, Zhengzhou 451100, China
  • 2. School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology, Zhengzhou 451100, China
  • 3. Zhengzhou Ecological Environment Bureau Xinzheng Branch, Zhengzhou 451100, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0575
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A new alkaloid (1) and six known compounds (2-7) were isolated from the solid fermentation extract of the endophytic fungus Alternaria tenuissima Pas85 of Phragmites australis by silica gel column chromatography, Sephadex LH-20 column chromatography, high performance liquid chromatography and other chromatographic techniques. The structures of these compounds were determined by HREIMS, NMR, IR spectroscopy, and literature comparison, and the anti MRSA (methicillin-resistant Staphylococcus aureus) activity of 1-5 were tested. Compounds 1, 2, 3 and 4 exhibited certain inhibitory activity with MIC values of 64, 4, 32 and 32 μg·mL-1, respectively, and compound 5 showed no significant inhibitory activity.

Phragmites australis  /  endophytic fungus  /  Alternaria tenuissima  /  secondary metabolite  /  anti methicillin-resistant Staphylococcus aureus
Ya-ling JIANG, Wei-ping LI, Cheng-cheng HU, Xue-ru GUO, Yang WANG, Xin-xin ZHANG, Ke LI, Wen-yuan LI. Study on secondary metabolites of an endophytic fungi Alternaria tenuissima Pas85[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3330 -3334 . DOI: 10.16438/j.0513-4870.2024-0575
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Year 2024 volume 59 Issue 12
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doi: 10.16438/j.0513-4870.2024-0575
  • Receive Date：2024-06-19
  • Online Date：2025-11-24
  • Published：2024-12-12
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History
  • Received：2024-06-19
  • Revised：2024-09-20
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Affiliations
    1. Henan Engineering Research Center of Water Environment and Health, Zhengzhou University of Industrial Technology, Zhengzhou 451100, China
    2. School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology, Zhengzhou 451100, China
    3. Zhengzhou Ecological Environment Bureau Xinzheng Branch, Zhengzhou 451100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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