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Advances and clinical transformation of microsphere drug delivery systems
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Qi-long WU1, 2, Wen-yue LAN2, 4, Ming-jie CUI2, 3, Jun-jue WANG1, 2, Wen-hao CHENG2, Hai-jun YU1, 2, 3, 4, *
Acta Pharmaceutica Sinica | 2024, 59(12) : 3242 - 3250
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Acta Pharmaceutica Sinica | 2024, 59(12): 3242-3250
Advances and clinical transformation of microsphere drug delivery systems
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Qi-long WU1, 2, Wen-yue LAN2, 4, Ming-jie CUI2, 3, Jun-jue WANG1, 2, Wen-hao CHENG2, Hai-jun YU1, 2, 3, 4, *
Affiliations
  • 1. Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 3. Shenyang Pharmaceutical University, Shenyang 110016, China
  • 4. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0380
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The microsphere drug delivery systems have been extensively exploited for providing controllable drug release kinetics, enhancing drug stability and localized drug delivery. In past decade, dozens of microsphere drug delivery systems have been developed for clinical therapy of cancer, schizophrenia and neurodegenerative diseases (e.g., Alzheimer's disease and Parkinsonism). In this review article, we comprehensively summarized the fabrication methods of drug delivery systems and highlighted their advances for clinical application. Furthermore, we analyzed the potential and the challenges for clinical translation of the drug delivery systems.

microsphere drug delivery system  /  fabrication method  /  localized drug delivery  /  drug deposit  /  clinical translation
Qi-long WU, Wen-yue LAN, Ming-jie CUI, Jun-jue WANG, Wen-hao CHENG, Hai-jun YU. Advances and clinical transformation of microsphere drug delivery systems[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3242 -3250 . DOI: 10.16438/j.0513-4870.2024-0380
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Article Info
doi: 10.16438/j.0513-4870.2024-0380
  • Receive Date：2024-04-19
  • Online Date：2025-11-24
  • Published：2024-12-12
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History
  • Received：2024-04-19
  • Revised：2024-08-02
Funding
Affiliations
    1. Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    3. Shenyang Pharmaceutical University, Shenyang 110016, China
    4. University of Chinese Academy of Sciences, Beijing 100049, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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