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A new alkaloid from Huperzia serrata and its biological activity
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Xiao-ting QIAO1, 2, Xin-xin CHENG1, Dan WANG1, Mei-han LAI2, Jia-qi WANG2, Xiao-min WANG1, 2, Cai-lian RUAN2, Duo CAO1, *
Acta Pharmaceutica Sinica | 2024, 59(12) : 3342 - 3346
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Acta Pharmaceutica Sinica | 2024, 59(12): 3342-3346
A new alkaloid from Huperzia serrata and its biological activity
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Xiao-ting QIAO1, 2, Xin-xin CHENG1, Dan WANG1, Mei-han LAI2, Jia-qi WANG2, Xiao-min WANG1, 2, Cai-lian RUAN2, Duo CAO1, *
Affiliations
  • 1. Shaanxi Key Laboratory of Research and Utilization of Resource Plants on the Loess Plateau, Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University, Yan'an 716000, China
  • 2. Medical School of Yan'an University, Yan'an 716000, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0843
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The methanol extract of Huperzia serrata was separated and purified by ODS, AB-8 macroporous adsorption resin, dextran gel Sephadex LH-20 and silica gel column chromatography combined with the semi-pre HPLC. The chemical structures of the isolated compounds were identified by MS, IR, NMR, etc. Four compounds were isolated from Huperzia serrata and identified, named as serratinine C (1), lycobeline C (2), diphaladin A (3) and crenatine (4). Compound 1 is a new alkaloid, compounds 2-4 were isolated for the first time. In vitro biological activity experiments showed that compound 1 could significantly reduce the levels of nitric oxide and reactive oxygen species in glial cells induced by lipopolysaccharide and had significant antioxidant biological activity.

Huperzia serrata  /  chemical composition  /  alkaloid  /  structural identification  /  antioxidant
Xiao-ting QIAO, Xin-xin CHENG, Dan WANG, Mei-han LAI, Jia-qi WANG, Xiao-min WANG, Cai-lian RUAN, Duo CAO. A new alkaloid from Huperzia serrata and its biological activity[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3342 -3346 . DOI: 10.16438/j.0513-4870.2024-0843
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doi: 10.16438/j.0513-4870.2024-0843
  • Receive Date：2024-08-30
  • Online Date：2025-11-24
  • Published：2024-12-12
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History
  • Received：2024-08-30
  • Revised：2024-10-18
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Affiliations
    1. Shaanxi Key Laboratory of Research and Utilization of Resource Plants on the Loess Plateau, Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University, Yan'an 716000, China
    2. Medical School of Yan'an University, Yan'an 716000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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