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A new pregnane steroid from Poria cocos
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Chao-yuan XIAO1, 2, Zhi-you HAO1, 2, Meng YANG1, 2, Shi-qi ZHOU1, 2, Jun-yang ZHANG1, 2, Xiao-ke ZHENG1, 2, Yan-jun SUN1, 2, 3, *, Wei-sheng FENG1, 2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(12) : 3325 - 3329
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Acta Pharmaceutica Sinica | 2024, 59(12): 3325-3329
A new pregnane steroid from Poria cocos
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Chao-yuan XIAO1, 2, Zhi-you HAO1, 2, Meng YANG1, 2, Shi-qi ZHOU1, 2, Jun-yang ZHANG1, 2, Xiao-ke ZHENG1, 2, Yan-jun SUN1, 2, 3, *, Wei-sheng FENG1, 2, 3, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
  • 3. Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou 450046, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0466
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The 95% ethanol extract of Poria cocos was separated and purified by ODS, MCI gel CHP20 and silica gel column chromatography combined with the semi-preparative HPLC. The chemical structures of the isolated compounds were identified by NMR, MS, IR, and calculated NMR methods. Seven compounds were isolated from Poria cocos and identified as 20S-2β, 3α, 15α, 19, 20-hydroxy-pregnane-7-ene (1), dehydroeburicoic acid monoacetate (2), eburicoic acid acetate (3), dehydroeburicoic acid (4), eburicoic acid (5), dehydropachymic acid (6), pachymic acid (7). Compound 1 is a new pregnane steroid.

Poria cocos  /  chemical constituent  /  pregnane steroid  /  tetracyclic triterpenoid  /  structural identification
Chao-yuan XIAO, Zhi-you HAO, Meng YANG, Shi-qi ZHOU, Jun-yang ZHANG, Xiao-ke ZHENG, Yan-jun SUN, Wei-sheng FENG. A new pregnane steroid from Poria cocos[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3325 -3329 . DOI: 10.16438/j.0513-4870.2024-0466
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doi: 10.16438/j.0513-4870.2024-0466
  • Receive Date：2024-05-15
  • Online Date：2025-11-24
  • Published：2024-12-12
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History
  • Received：2024-05-15
  • Revised：2024-08-16
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
    3. Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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