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Therapeutic effect and mechanism of Shiwei-Ruxiang-capsule on rheumatoid arthritis based on intestinal flora and metabolomics
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Yu-han GAO1, Hai-juan CHEN1, 2, *, Yong-gui MA1, 2, Jun SHANG1, 2, Guo-yan ZHANG1, 2, Wen-jian ZHANG1
Acta Pharmaceutica Sinica | 2024, 59(12) : 3304 - 3314
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Acta Pharmaceutica Sinica | 2024, 59(12): 3304-3314
Therapeutic effect and mechanism of Shiwei-Ruxiang-capsule on rheumatoid arthritis based on intestinal flora and metabolomics
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Yu-han GAO1, Hai-juan CHEN1, 2, *, Yong-gui MA1, 2, Jun SHANG1, 2, Guo-yan ZHANG1, 2, Wen-jian ZHANG1
Affiliations
  • 1. Key Laboratory of Medicinal Animal and Plant Resources in Qinghai Tibet Plateau, School of Life Sciences, Qinghai Normal University, Xining 810008, China
  • 2. Academy of Plateau Science and Sustainability, Xining 810008, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0685
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Shiwei-Ruxiang-capsule (SWRXC) is a classic formulation widely used in the treatment of rheumatoid arthritis (RA). The study used liquid chromatography-tandem mass spectrometry (LC-MS/MS) serum untargeted metabolomics and high-throughput 16S rRNA gene sequencing association analysis to elucidate the mechanism of action of SWRXC for the treatment of Freund's complete adjuvant-induced RA. The results showed that SWRXC significantly improved symptoms and reduced serum cytokine levels in RA rats. Based on LC-MS/MS technology, metabolomics identified tryptophan metabolism, nucleotide metabolism and purine metabolism as the most relevant pathways for treatment. In addition, 16S rRNA sequencing results showed that SWRXC could ameliorate RA-induced intestinal microbial oncogenesis in rats. In conclusion, SWRXC can improve the morphology and structure of RA joint tissues, reduce serum factor levels, and may play a role in improving RA by modulating related metabolic pathways such as tryptophan metabolism, nucleotide metabolism and purine metabolism, and altering the composition of intestinal flora. Animal protocols were approved by the Animal Ethics Committee of Qinghai Normal University (No. 2021041203).

Shiwei-Ruxiang-capsule  /  rheumatoid arthritis  /  intestinal flora  /  non-targeted metabolomics  /  mechanism
Yu-han GAO, Hai-juan CHEN, Yong-gui MA, Jun SHANG, Guo-yan ZHANG, Wen-jian ZHANG. Therapeutic effect and mechanism of Shiwei-Ruxiang-capsule on rheumatoid arthritis based on intestinal flora and metabolomics[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3304 -3314 . DOI: 10.16438/j.0513-4870.2024-0685
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doi: 10.16438/j.0513-4870.2024-0685
  • Receive Date：2024-07-17
  • Online Date：2025-11-24
  • Published：2024-12-12
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  • Received：2024-07-17
  • Revised：2024-10-09
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Affiliations
    1. Key Laboratory of Medicinal Animal and Plant Resources in Qinghai Tibet Plateau, School of Life Sciences, Qinghai Normal University, Xining 810008, China
    2. Academy of Plateau Science and Sustainability, Xining 810008, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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