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Research progress in drug carriers across the blood-brain barrier
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Wan-xin CAO1, Yi-hui YANG1, Hong YANG1, Sen ZHANG1, Yi-zhi ZHANG1, Fang XU1, Wan LI1, Yue HAO1, Xiao-xue LI1, 2, Xu ZHANG1, Guan-hua DU1, Jin-hua WANG1, *
Acta Pharmaceutica Sinica | 2024, 59(12) : 3222 - 3231
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Acta Pharmaceutica Sinica | 2024, 59(12): 3222-3231
Research progress in drug carriers across the blood-brain barrier
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Wan-xin CAO1, Yi-hui YANG1, Hong YANG1, Sen ZHANG1, Yi-zhi ZHANG1, Fang XU1, Wan LI1, Yue HAO1, Xiao-xue LI1, 2, Xu ZHANG1, Guan-hua DU1, Jin-hua WANG1, *
Affiliations
  • 1. Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Shenyang Pharmaceutical University, Shenyang 117004, China
Published: 2024-12-12 doi: 10.16438/j.0513-4870.2024-0732
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The blood-brain barrier (BBB) plays a crucial role in maintaining the homeostasis of the brain's internal environment, which poses challenges to the treatment of central nervous system diseases. Drug carriers can aid in the delivery of therapeutic agents across the BBB to exert their pharmacological effects. The article reviewed the pathways for drug delivery across the BBB, the intracerebral fate and the classification of drug carriers and focuses on the functions and characteristics of liposomes, exosomes, apoptotic bodies, cell-penetrating peptides, and cell-targeting peptides. The review will provide an outlook on the future and challenge of research in the field of drug delivery across the BBB.

drug carrier  /  blood-brain barrier  /  intracerebral fate  /  liposome  /  exosome  /  apoptotic body  /  cell-penetrating peptide  /  cell-targeting peptide
Wan-xin CAO, Yi-hui YANG, Hong YANG, Sen ZHANG, Yi-zhi ZHANG, Fang XU, Wan LI, Yue HAO, Xiao-xue LI, Xu ZHANG, Guan-hua DU, Jin-hua WANG. Research progress in drug carriers across the blood-brain barrier[J]. Acta Pharmaceutica Sinica, 2024 , 59 (12) : 3222 -3231 . DOI: 10.16438/j.0513-4870.2024-0732
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Year 2024 volume 59 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2024-0732
  • Receive Date：2024-07-30
  • Online Date：2025-11-24
  • Published：2024-12-12
Article Data
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History
  • Received：2024-07-30
  • Revised：2024-09-27
Funding
Affiliations
    1. Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Shenyang Pharmaceutical University, Shenyang 117004, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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