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Three new anthraquinones from Prismatomeris tetrandra (Roxb.) K. Schum and their protective effects in neuroblastoma cells
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Xin-yi CHEN1, Chen ZHANG2, Yi-rong DONG1, Ying-da ZANG1, Jia-qi CHEN1, Hong-tao JIN2, 3, *, Dong-ming ZHANG1, *
Acta Pharmaceutica Sinica | 2023, 58(12) : 3710 - 3714
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Acta Pharmaceutica Sinica | 2023, 58(12): 3710-3714
Three new anthraquinones from Prismatomeris tetrandra (Roxb.) K. Schum and their protective effects in neuroblastoma cells
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Xin-yi CHEN1, Chen ZHANG2, Yi-rong DONG1, Ying-da ZANG1, Jia-qi CHEN1, Hong-tao JIN2, 3, *, Dong-ming ZHANG1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Beijing Union-Genius Pharmaceutical Technology Development Co., Ltd., Beijing 100176, China
  • 3. New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-12-12 doi: 10.16438/j.0513-4870.2023-1104
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Three new anthraquinones were isolated from the 80% ethanol extract of Prismatomeris tetrandra by silica gel, MCI, ODS column chromatography and high performance preparative liquid chromatography (HPLC). The structures of the new compounds were identified by mass spectrometry, nuclear magnetic resonance and other spectroscopic methods as 6-hydroxy-1,2,3-trimethoxy-7-methylanthracene-9,10-dione (1), 6-(hydroxymethyl)-1,2,3-trimethoxyanthracene-9,10-dione (2) and 7-hydroxy-6-(hydroxymethyl)-1,2-dimethoxyanthracene-9,10-dione (3). Compounds 1, 2 and 3 showed protective effects against monosodium glutamate-induced damage in SH-SY5Y neuroblastoma cells, with the cell survival rates elevated 18.45%, 4.31%, and 7.65%, respectively.

Prismatomeris tetrandra  /  chemical composition  /  anthraquinone  /  neuroprotection
Xin-yi CHEN, Chen ZHANG, Yi-rong DONG, Ying-da ZANG, Jia-qi CHEN, Hong-tao JIN, Dong-ming ZHANG. Three new anthraquinones from Prismatomeris tetrandra (Roxb.) K. Schum and their protective effects in neuroblastoma cells[J]. Acta Pharmaceutica Sinica, 2023 , 58 (12) : 3710 -3714 . DOI: 10.16438/j.0513-4870.2023-1104
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doi: 10.16438/j.0513-4870.2023-1104
  • Receive Date：2023-09-26
  • Online Date：2025-11-21
  • Published：2023-12-12
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  • Received：2023-09-26
  • Revised：2023-10-11
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Beijing Union-Genius Pharmaceutical Technology Development Co., Ltd., Beijing 100176, China
    3. New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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