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Improvement effect of diterpene ginkgolides on acute tMCAO rats and chronic tMCAO rats
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Ling WANG, Shao-feng XU, Nan FENG, Wei-ping WANG, Jie CAI, Xiao-liang WANG*
Acta Pharmaceutica Sinica | 2023, 58(12) : 3669 - 3673
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Acta Pharmaceutica Sinica | 2023, 58(12): 3669-3673
Improvement effect of diterpene ginkgolides on acute tMCAO rats and chronic tMCAO rats
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Ling WANG, Shao-feng XU, Nan FENG, Wei-ping WANG, Jie CAI, Xiao-liang WANG*
Affiliations
  • Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150), Beijing 100050, China
Published: 2023-12-12 doi: 10.16438/j.0513-4870.2023-0905
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To study the cognitive effects of diterpene ginkgolides (DG), transient middle cerebral artery occlusion (tMCAO)-induced rats were established. tMCAO-rats induced by suture method were divided into sham operation group, solvent control group, NBP group, DG group. The animal experiments in the present study were performed in accordance with the Ethical Guidelines of the Laboratory Animal Welfare Ethical Committee of Peking Union Medical College (00000646, 00000635). The effects of DG on tMCAO rats were evaluated by neurological severity score, cerebral infarction volume measurement, step-down and Morris water maze test. In the acute tMCAO rat model, 100 mg·kg-1 DG improved the neural score and infarction volume. In the chronic tMCAO rat model, DG 100 mg·kg-1 significantly improved the survival rate of tMCAO-induced rats. The Morris water maze results showed 100 mg·kg-1 DG decreased the latency of tMCAO-induced rats to find the platform, while the effect was weaker than the NBP. However, DG 30 mg·kg-1 did not show a significant effect. In conclusion, DG exerted a therapeutic effect on transient middle cerebral artery occlusion.

transient middle cerebral artery occlusion  /  diterpene ginkgolides  /  learning and memory  /  vascular dementia  /  cerebral protection
Ling WANG, Shao-feng XU, Nan FENG, Wei-ping WANG, Jie CAI, Xiao-liang WANG. Improvement effect of diterpene ginkgolides on acute tMCAO rats and chronic tMCAO rats[J]. Acta Pharmaceutica Sinica, 2023 , 58 (12) : 3669 -3673 . DOI: 10.16438/j.0513-4870.2023-0905
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Year 2023 volume 58 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2023-0905
  • Receive Date：2023-07-25
  • Online Date：2025-11-21
  • Published：2023-12-12
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  • Received：2023-07-25
  • Revised：2023-09-22
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    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150), Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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