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Bioorthogonal click-to-release reaction for regulating iodo-BODIPY PDT probe
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Xin-yu YU1, Jie LI1, Yue LI2, Ya-yue WANG1, Wei SHI3, *, Hao-xing WU1, *
Acta Pharmaceutica Sinica | 2023, 58(11) : 3400 - 3407
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Acta Pharmaceutica Sinica | 2023, 58(11): 3400-3407
• Original Articles •
Bioorthogonal click-to-release reaction for regulating iodo-BODIPY PDT probe
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Xin-yu YU1, Jie LI1, Yue LI2, Ya-yue WANG1, Wei SHI3, *, Hao-xing WU1, *
Affiliations
  • 1. Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu 610041, China
  • 2. Research Core Facility of West China Hospital, Sichuan University, Chengdu 610041, China
  • 3. Institute of Drug Clinical Trial·GCP, West China Second University Hospital, Sichuan University, Chengdu 610041, China
Published: 2023-11-12 doi: 10.16438/j.0513-4870.2023-1071
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In this study, we synthesized six tetrazine-dipyrromethene boron difluoride (BODIPY) probes and achieved a remarkable up to 14-fold increase in singlet oxygen yield via tetrazine bioorthogonal click-to-release reactions. We systematically investigated the photodynamic activity of these probes, revealing crucial structure-activity relationships. Additionally, we evaluated the stability and release kinetics of these probes and identified P5 and P6 as ideal candidates for photodynamic therapy in live cells. This innovative strategy opens new avenues for fine-tuning the photodynamic properties of BODIPY dyes, thereby expanding their utility in cancer therapy.

photodynamic therapy probe  /  bioorthogonal reaction  /  dipyrromethene boron difluoride  /  click-to-release reaction  /  tetrazine
Xin-yu YU, Jie LI, Yue LI, Ya-yue WANG, Wei SHI, Hao-xing WU. Bioorthogonal click-to-release reaction for regulating iodo-BODIPY PDT probe[J]. Acta Pharmaceutica Sinica, 2023 , 58 (11) : 3400 -3407 . DOI: 10.16438/j.0513-4870.2023-1071
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Article Info
doi: 10.16438/j.0513-4870.2023-1071
  • Receive Date：2023-09-14
  • Online Date：2025-11-21
  • Published：2023-11-12
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History
  • Received：2023-09-14
  • Revised：2023-10-08
Funding
Affiliations
    1. Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu 610041, China
    2. Research Core Facility of West China Hospital, Sichuan University, Chengdu 610041, China
    3. Institute of Drug Clinical Trial·GCP, West China Second University Hospital, Sichuan University, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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