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Recent advances of small molecule inhibitors directly targeting HBV
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Jia-hui ZHOU, Shuo WANG, Dang DING, Xiang-rui XU, Shu-jing XU, Yong HE, Xin-yong LIU*, Peng ZHAN*
Acta Pharmaceutica Sinica | 2023, 58(11) : 3270 - 3284
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Acta Pharmaceutica Sinica | 2023, 58(11): 3270-3284
• Reviews •
Recent advances of small molecule inhibitors directly targeting HBV
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Jia-hui ZHOU, Shuo WANG, Dang DING, Xiang-rui XU, Shu-jing XU, Yong HE, Xin-yong LIU*, Peng ZHAN*
Affiliations
  • Key laboratory of Chemical Biology(Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2023-11-12 doi: 10.16438/j.0513-4870.2023-0111
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Hepatitis B virus infection is a serious threat to human life and health. The approved anti-HBV drugs including interferons and nucleos(t)ide analogues have serious adverse effect, rebound phenomena after drug withdrawal, and drug resistance. And the cccDNA cannot be completely eliminated by both of them, which is the reason why a complete cure for hepatitis B cannot be achieved. Therefore, developing anti-HBV drugs directly targeting protein or nucleic acid of HBV remains a current public health priority. Based on the analysis of representative literature from the last decade, this article reviews recent developments in small molecule inhibitors directly targeting HBV from a medicinal chemistry perspective.

Hepatitis B virus  /  inhibitor  /  drug target  /  medicinal chemistry  /  drug design
Jia-hui ZHOU, Shuo WANG, Dang DING, Xiang-rui XU, Shu-jing XU, Yong HE, Xin-yong LIU, Peng ZHAN. Recent advances of small molecule inhibitors directly targeting HBV[J]. Acta Pharmaceutica Sinica, 2023 , 58 (11) : 3270 -3284 . DOI: 10.16438/j.0513-4870.2023-0111
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Year 2023 volume 58 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2023-0111
  • Receive Date：2023-02-05
  • Online Date：2025-11-21
  • Published：2023-11-12
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  • Received：2023-02-05
  • Revised：2023-03-21
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    Key laboratory of Chemical Biology(Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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