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Advances on toxicity and metabolism of alkaloids from the "toxic" traditional Chinese medicines
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Yan CHEN1, Ying-ying TANG1, Li YANG1, Ai-zhen XIONG1, 2, *, Zheng-tao WANG1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(11) : 3285 - 3295
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Acta Pharmaceutica Sinica | 2023, 58(11): 3285-3295
• Reviews •
Advances on toxicity and metabolism of alkaloids from the "toxic" traditional Chinese medicines
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Yan CHEN1, Ying-ying TANG1, Li YANG1, Ai-zhen XIONG1, 2, *, Zheng-tao WANG1, 2, *
Affiliations
  • 1. The MOE Key Laboratory for SCMTA of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China
Published: 2023-11-12 doi: 10.16438/j.0513-4870.2023-0241
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The "toxicity" and safety of traditional Chinese medicines have been seriously concerned. Alkaloids are the main pharmacodynamic components of many kinds of traditional Chinese medicines, which show strong biological activity at low concentration. It will also cause toxic side effects but if used improperly. Some alkaloids are both active and toxic, and the safety of related traditional Chinese medicines is particularly noteworthy. The efficacy or toxicity of alkaloids may be the result of the combined action of parent compounds and metabolites, which is not only related to the structural types of compounds, but also has obvious species differences between humans and animals. This review focused on the alkaloids contained in the "toxic" traditional Chinese medicines that are officially recorded in Chinese Pharmacopoeia and the metabolism patterns of alkaloids with different structures as well as the enzymes involved were summarized and discussed by referencing the publications in recent two decades. The present study will be beneficial to the rational use of these traditional Chinese medicines in clinic.

safety of traditional Chinese medicine  /  alkaloid  /  drug metabolism  /  detoxification  /  metabolic enzyme
Yan CHEN, Ying-ying TANG, Li YANG, Ai-zhen XIONG, Zheng-tao WANG. Advances on toxicity and metabolism of alkaloids from the "toxic" traditional Chinese medicines[J]. Acta Pharmaceutica Sinica, 2023 , 58 (11) : 3285 -3295 . DOI: 10.16438/j.0513-4870.2023-0241
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Article Info
doi: 10.16438/j.0513-4870.2023-0241
  • Receive Date：2023-03-01
  • Online Date：2025-11-21
  • Published：2023-11-12
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History
  • Received：2023-03-01
  • Revised：2023-07-12
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Affiliations
    1. The MOE Key Laboratory for SCMTA of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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