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Formulation optimization and analysis of taste-masking effect of licorzine granules based on sensory evaluation and electronic tongue method
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Li-min WANG1, Shu-ye QI2, Wei-feng ZHANG1, 3, Peng SHEN1, Bao-ming NING2, Da-yong SHI1, Xue-ping WU1, *, Jie YANG1, 3, *
Acta Pharmaceutica Sinica | 2023, 58(11) : 3191 - 3197
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Acta Pharmaceutica Sinica | 2023, 58(11): 3191-3197
• Special Reports: Pharmaceutical Taste-Masking and Assessment Technologies •
Formulation optimization and analysis of taste-masking effect of licorzine granules based on sensory evaluation and electronic tongue method
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Li-min WANG1, Shu-ye QI2, Wei-feng ZHANG1, 3, Peng SHEN1, Bao-ming NING2, Da-yong SHI1, Xue-ping WU1, *, Jie YANG1, 3, *
Affiliations
  • 1. Shandong DYNE Marine Biopharmaceutical Co., Ltd., Weihai 264300, China
  • 2. National Institutes for Food and Drug Control, Beijing 102629, China
  • 3. Beijing DYNE High-tech Pediatric Pharmaceutical R & D Institute Co., Ltd., Beijing 100176, China
Published: 2023-11-12 doi: 10.16438/j.0513-4870.2023-0408
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Licorzine granules are common preparations for children zinc deficiency. Considering the long course of treatment, the taste of licorzine granules may become a main factor affecting medication adherence. To date there have been no taste evaluation research into licorzine granules yet. In this study, both sensory evaluation and electronic tongue method were utilized to optimize licorzine granules formulations, evaluate the tastes of licorzine, excipients, optimized formulation in vivo and in vitro. As the results show, bitterness and astringency are the main unpleasant tastes generating from licorzine. Xanthan gum is the main taste-masking excipient, lowering down the bitterness and astringency of licorzine by at least one grade. Good correlation exists between the results of sensory evaluation and electronic tongue method, and an integrated combination of the two helps to obtain objective and rational research conclusions. The adult sensory evaluation study was a research-based clinical trial conducted with informed consent from all subjects in accordance with the ethical requirements of Good Clinical Practice.

licorzine  /  licorzine granule  /  sensory evaluation  /  electronic tongue  /  formulation optimization  /  taste-masking  /  xanthan gum
Li-min WANG, Shu-ye QI, Wei-feng ZHANG, Peng SHEN, Bao-ming NING, Da-yong SHI, Xue-ping WU, Jie YANG. Formulation optimization and analysis of taste-masking effect of licorzine granules based on sensory evaluation and electronic tongue method[J]. Acta Pharmaceutica Sinica, 2023 , 58 (11) : 3191 -3197 . DOI: 10.16438/j.0513-4870.2023-0408
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Article Info
doi: 10.16438/j.0513-4870.2023-0408
  • Receive Date：2023-04-04
  • Online Date：2025-11-21
  • Published：2023-11-12
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History
  • Received：2023-04-04
  • Revised：2023-06-02
Funding
Affiliations
    1. Shandong DYNE Marine Biopharmaceutical Co., Ltd., Weihai 264300, China
    2. National Institutes for Food and Drug Control, Beijing 102629, China
    3. Beijing DYNE High-tech Pediatric Pharmaceutical R & D Institute Co., Ltd., Beijing 100176, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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