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Research progress of anti-pulmonary fibrosis drugs targeting autotaxin-lysophosphatidic acid axis
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Hai-yan JIANG1, Lian KUANG1, Tian-yu ZHOU2, Hong-tao JIN1, 3, 4, *
Acta Pharmaceutica Sinica | 2023, 58(10) : 2961 - 2969
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Acta Pharmaceutica Sinica | 2023, 58(10): 2961-2969
Research progress of anti-pulmonary fibrosis drugs targeting autotaxin-lysophosphatidic acid axis
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Hai-yan JIANG1, Lian KUANG1, Tian-yu ZHOU2, Hong-tao JIN1, 3, 4, *
Affiliations
  • 1. New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. College of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
  • 3. NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug, Beijing 102206, China
  • 4. Beijing Union-Genius Pharmaceutical Technology Development Co. Ltd., Beijing 100176, China
Published: 2023-10-12 doi: 10.16438/j.0513-4870.2023-0022
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Pulmonary fibrosis is an interstitial lung disease characterized by inflammatory injury and tissue structure destruction. Currently, there is a lack of effective therapeutic drugs for pulmonary fibrosis, and the mechanism is still unknown. Therefore, it is urgent to seek new targets for effective drugs. In pulmonary fibrosis, the level of autotaxin (ATX) in bronchoalveolar lavage fluid increases and stimulates the production of lysophosphatidic acid (LPA). The involvement of LPA receptors in activating a variety of G-protein-mediated signal transduction pathways leads to a range of related physiological effects, including pro-inflammatory signaling in epithelial cells, activation of transforming growth factor signaling, and stimulation of fibroblast accumulation. LPA receptor antagonists and ATX inhibitors have been concerned as new targets for pulmonary fiber therapy, and currently related drugs have entered clinical trials. In this paper, the pathophysiological effects of LPA and ATX in pulmonary fibrosis disease and related drug development progress were reviewed to provide reference information of new drug development for pulmonary fibrosis based on the ATX-LPA axis.

autotaxin  /  lysophosphatidic acid  /  pulmonary fibrosis  /  inhibitor
Hai-yan JIANG, Lian KUANG, Tian-yu ZHOU, Hong-tao JIN. Research progress of anti-pulmonary fibrosis drugs targeting autotaxin-lysophosphatidic acid axis[J]. Acta Pharmaceutica Sinica, 2023 , 58 (10) : 2961 -2969 . DOI: 10.16438/j.0513-4870.2023-0022
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Article Info
doi: 10.16438/j.0513-4870.2023-0022
  • Receive Date：2023-01-09
  • Online Date：2025-11-21
  • Published：2023-10-12
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History
  • Received：2023-01-09
  • Revised：2023-05-19
Funding
Affiliations
    1. New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. College of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
    3. NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug, Beijing 102206, China
    4. Beijing Union-Genius Pharmaceutical Technology Development Co. Ltd., Beijing 100176, China
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https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2023-0022
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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