Home Journals Articles Updates About
CN
image
收藏切换
Identification of taste critical quality attribute and formulation optimization of Xiaoer Qingrening Granules based on electronic tongue and human senses
收藏切换
PDF
Xiao-yan HU1, Ying LU2, 3, Xiao-meng WANG2, 3, Li-juan MA2, 3, Yu-nan WEI2, 3, Ping DAI1, Chao-fu MA2, 3, Han ZHANG2, 3, Jing WANG2, 3, Nan LI2, 3, Xing-xing DAI2, 3, Lu YAO4, Bei-lei XU5, Wei XU1, *, Zhi-sheng WU1, 2, 3, *
Acta Pharmaceutica Sinica | 2023, 58(10) : 2875 - 2881
Less
收藏切换
Acta Pharmaceutica Sinica | 2023, 58(10): 2875-2881
Identification of taste critical quality attribute and formulation optimization of Xiaoer Qingrening Granules based on electronic tongue and human senses
Full
Xiao-yan HU1, Ying LU2, 3, Xiao-meng WANG2, 3, Li-juan MA2, 3, Yu-nan WEI2, 3, Ping DAI1, Chao-fu MA2, 3, Han ZHANG2, 3, Jing WANG2, 3, Nan LI2, 3, Xing-xing DAI2, 3, Lu YAO4, Bei-lei XU5, Wei XU1, *, Zhi-sheng WU1, 2, 3, *
Affiliations
  • 1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
  • 2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
  • 3. Engineering Research Center of Chinese Medicine Production and New Drug Development, Beijing 102488, China
  • 4. Beijing Tongrentang Technology Development Co., Ltd., Beijing 100079, China
  • 5. School of Pharmacy, Harbin University of Commerce, Harbin 150076, China
Published: 2023-10-12 doi: 10.16438/j.0513-4870.2022-1329
Outline
收藏切换

This study primarily concentrated on scientific problems of poor taste caused by unclear critical quality attributes of oral preparations manufactured by Chinese materia medica, successfully established an identification method for taste critical quality attribute and a taste improvement method combining electronic tongue with human senses, and determined the optimal taste formula, to improve patients' oral medication compliance. The study received ethical approval from the Review Committee of the Beijing University of Chinese Medicine. The results showed that the proportion of bitterness of Xiaoer Qingrening Granule was 61.8%, and its bitterness grade was 3.70, it was determined that bitterness is the critical quality attribute that caused the poor taste of Xiaoer Qingrening Granule. Additionally, the optimal taste formula per milliliter of Xiaoer Qingrening sugar-free intermediate was determined with allowable daily intake, solubility, and sweetness as the limiting conditions, which was 40 mg hydroxypropyl β-cyclodextrin, 180 mg trehalose, and 1.5 mg acesulfame potassium. Compared with the Xiaoer Qingrening Granule, the sensory evaluation score of the optimal taste formula was increased by 37.5 points. In conclusion, this study achieved the taste improvement of Xiaoer Qingrening Granule and formed a set of taste improvement strategies including the identification of taste critical quality attribute, the selection of the type and dosage of corrigent, and the optimization of taste formula, which provided a thought reference for the taste improvement of other oral preparations and a new perspective for quality control of intelligent manufacturing of traditional Chinese medicines.

oral preparation  /  electronic tongue  /  human sense  /  bitterness  /  critical quality attribute
Xiao-yan HU, Ying LU, Xiao-meng WANG, Li-juan MA, Yu-nan WEI, Ping DAI, Chao-fu MA, Han ZHANG, Jing WANG, Nan LI, Xing-xing DAI, Lu YAO, Bei-lei XU, Wei XU, Zhi-sheng WU. Identification of taste critical quality attribute and formulation optimization of Xiaoer Qingrening Granules based on electronic tongue and human senses[J]. Acta Pharmaceutica Sinica, 2023 , 58 (10) : 2875 -2881 . DOI: 10.16438/j.0513-4870.2022-1329
Appendix
Less
Year 2023 volume 58 Issue 10
PDF
456
320
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-1329
  • Receive Date：2022-12-05
  • Online Date：2025-11-21
  • Published：2023-10-12
Article Data
Affiliations
History
  • Received：2022-12-05
  • Revised：2023-02-08
Funding
Affiliations
    1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
    2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
    3. Engineering Research Center of Chinese Medicine Production and New Drug Development, Beijing 102488, China
    4. Beijing Tongrentang Technology Development Co., Ltd., Beijing 100079, China
    5. School of Pharmacy, Harbin University of Commerce, Harbin 150076, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-1329
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House