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Research progress of anti-tumor in situ gel delivery system
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Cong-cong XIAO, Chen-fei LIU, Jing FENG, Li-qing CHEN, He-ming ZHAO, Ming-ji JIN, Zhong-gao GAO, Wei HUANG*
Acta Pharmaceutica Sinica | 2023, 58(10) : 3004 - 3015
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Acta Pharmaceutica Sinica | 2023, 58(10): 3004-3015
Research progress of anti-tumor in situ gel delivery system
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Cong-cong XIAO, Chen-fei LIU, Jing FENG, Li-qing CHEN, He-ming ZHAO, Ming-ji JIN, Zhong-gao GAO, Wei HUANG*
Affiliations
  • Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-10-12 doi: 10.16438/j.0513-4870.2023-0550
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Cancer is the most important leading cause of death worldwide, with about 10 million deaths caused by cancer in 2020. In situ gel drug delivery systems have attracted much attention in the field of pharmacy and biotechnology due to their good histo-compatibility, excellent injectability, high drug delivery capacity, slow-release drug delivery, and less influence by the in vivo environment. Meanwhile, in situ gel can be combined with chemotherapy, photo-thermal therapy, chemokinetic therapy, immunotherapy and so on to deliver drugs into the tumor site in a less invasive way without surgical operation, forming a semi-solid gel reservoir in the tumor site to realize in situ tumor combined therapy. In this paper, the author summarized the research progress of anti-tumor in situ gel delivery system in the past 10 years, introduced its commonly used polymer materials, classification principles and specific application examples, and finally summarized and discussed the key issues, in order to provide reference for the development of new anti-tumor drug delivery system in the future.

in situ gel  /  drug delivery system  /  cancer  /  anti-tumor  /  combination therapy
Cong-cong XIAO, Chen-fei LIU, Jing FENG, Li-qing CHEN, He-ming ZHAO, Ming-ji JIN, Zhong-gao GAO, Wei HUANG. Research progress of anti-tumor in situ gel delivery system[J]. Acta Pharmaceutica Sinica, 2023 , 58 (10) : 3004 -3015 . DOI: 10.16438/j.0513-4870.2023-0550
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Article Info
doi: 10.16438/j.0513-4870.2023-0550
  • Receive Date：2023-05-03
  • Online Date：2025-11-21
  • Published：2023-10-12
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  • Received：2023-05-03
  • Revised：2023-05-23
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    Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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