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Advances in research on small molecule regulators targeting HBV cccDNA generation and transcription
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Xiang-rui XU, Yu JIN, Shu-jing XU, Shuo WANG, Yong HE, Xin-yong LIU*, Peng ZHAN*
Acta Pharmaceutica Sinica | 2023, 58(10) : 2979 - 2994
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Acta Pharmaceutica Sinica | 2023, 58(10): 2979-2994
Advances in research on small molecule regulators targeting HBV cccDNA generation and transcription
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Xiang-rui XU, Yu JIN, Shu-jing XU, Shuo WANG, Yong HE, Xin-yong LIU*, Peng ZHAN*
Affiliations
  • Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2023-10-12 doi: 10.16438/j.0513-4870.2023-0094
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Hepatitis B virus (HBV) represents a significant global public health challenge. Despite the availability of several approved drugs for hepatitis B treatment, the persistence of covalently closed circular DNA (cccDNA) renders HBV eradication elusive, thereby leading to disease relapse after drug withdrawal. This paper reviews the regulatory mechanisms of cccDNA formation, transcription and replication, and summarizes the research progress of related small molecule regulators from the perspective of medicinal chemistry.

hepatitis B virus  /  covalently closed circular DNA  /  small molecule  /  medicinal chemistry  /  drug design
Xiang-rui XU, Yu JIN, Shu-jing XU, Shuo WANG, Yong HE, Xin-yong LIU, Peng ZHAN. Advances in research on small molecule regulators targeting HBV cccDNA generation and transcription[J]. Acta Pharmaceutica Sinica, 2023 , 58 (10) : 2979 -2994 . DOI: 10.16438/j.0513-4870.2023-0094
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Year 2023 volume 58 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2023-0094
  • Receive Date：2023-02-01
  • Online Date：2025-11-21
  • Published：2023-10-12
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  • Received：2023-02-01
  • Revised：2023-04-17
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    Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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