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Study on release and antioxidant activity of quercetin after loaded by hot alkali hydrolysis modified UiO-66 material
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Rui-miao CHANG1, 2, 3, Yan-yang ZHANG4, An-juan KANG1, Guang-bin ZHANG1, Yan-ping YU1, Jun-zhao REN1, An-jia CHEN1, Yong LI2, 3, *
Acta Pharmaceutica Sinica | 2023, 58(9) : 2802 - 2810
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Acta Pharmaceutica Sinica | 2023, 58(9): 2802-2810
Study on release and antioxidant activity of quercetin after loaded by hot alkali hydrolysis modified UiO-66 material
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Rui-miao CHANG1, 2, 3, Yan-yang ZHANG4, An-juan KANG1, Guang-bin ZHANG1, Yan-ping YU1, Jun-zhao REN1, An-jia CHEN1, Yong LI2, 3, *
Affiliations
  • 1. School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
  • 2. Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Third Hospital of Shanxi Medical University, Taiyuan 030032, China
  • 3. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 4. Shanxi Liye Pharmaceutical Co., Ltd., Taiyuan 030021, China
Published: 2023-09-12 doi: 10.16438/j.0513-4870.2023-0101
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UiO-66 (University of Oslo 66) is a kind of promising material that can improve the release and bioavailability of poorly water-soluble bioactive compounds of traditional Chinese medicine. However, the loading of quercetin in raw UiO-66 was not ideal. In this study, UiO-66-BH (UiO-66-blend-heating) was obtained by heating UiO-66 and KOH solution following blended them. UiO-66-BH maintained the outline of octahedral structure of UiO-66 but with obvious rough and uneven pores on the surface. UiO-66-BH had good adsorption of quercetin with saturation adsorption was 138.92 mg·g-1, the adsorption process belonged to single molecular layer adsorption and was controlled by chemisorption. UiO-66-BH can control the release of quercetin in simulated gastrointestinal fluid, and the drug concentration was significantly higher than that of free quercetin after long-term release (36% vs 9%). Compared with quercetin, the ABTS (2, 2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) ammonium salt) radical scavenging activity of UiO-66-BH@quercetin drug delivery system decreased, while the DPPH (1, 1-diphenyl-2-picrylhydrazyl) radical scavenging activity remained almost unchanged. The drug delivery system showed a strong antioxidant effect similar to quercetin. The findings indicated that UiO-66-BH could control release of quercetin and was expected to be used as a drug carrier material for some insoluble active components of traditional Chinese medicine such as quercetin.

quercetin  /  UiO-66  /  thermal alkaline hydrolysis  /  adsorption performance  /  antioxidant activity  /  in-vitro release
Rui-miao CHANG, Yan-yang ZHANG, An-juan KANG, Guang-bin ZHANG, Yan-ping YU, Jun-zhao REN, An-jia CHEN, Yong LI. Study on release and antioxidant activity of quercetin after loaded by hot alkali hydrolysis modified UiO-66 material[J]. Acta Pharmaceutica Sinica, 2023 , 58 (9) : 2802 -2810 . DOI: 10.16438/j.0513-4870.2023-0101
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Year 2023 volume 58 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2023-0101
  • Receive Date：2023-02-02
  • Online Date：2025-11-21
  • Published：2023-09-12
Article Data
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History
  • Received：2023-02-02
  • Revised：2023-05-16
Funding
Affiliations
    1. School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
    2. Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Third Hospital of Shanxi Medical University, Taiyuan 030032, China
    3. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    4. Shanxi Liye Pharmaceutical Co., Ltd., Taiyuan 030021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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