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Current advances of CRISPR/Cas system in antibacterial field
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Zong-ti SUN, Lang SUN*, Xue-fu YOU*
Acta Pharmaceutica Sinica | 2023, 58(9) : 2560 - 2568
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Acta Pharmaceutica Sinica | 2023, 58(9): 2560-2568
Current advances of CRISPR/Cas system in antibacterial field
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Zong-ti SUN, Lang SUN*, Xue-fu YOU*
Affiliations
  • Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-09-12 doi: 10.16438/j.0513-4870.2023-0235
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A breakthrough in molecular biology for the twenty-first century is CRISPR/Cas gene editing, which has been used in a variety of fields due to its simplicity, adaptability, and targeting. Given the current global challenge of severe bacterial resistance, difficulties in detecting antimicrobial resistance, and slow development of antimicrobial drugs, CRISPR/Cas gene-editing technology offers a promising avenue for the development of antibacterial treatments. On the one hand, CRISPR/Cas gene editing technology helps advance the study of bacterial functions and serves as a toolbox. For instance, Cas proteins and exogenous repair systems enable efficient and precise gene editing, nCas proteins and deaminase systems facilitate template-free and single base precision editing, dCas proteins and reverse transcriptase allow for repair-free gene editing, and dCas proteins and modified sgRNA enable gene expression level regulation and gene function analysis. On the other hand, its specific gene recognition and targeted DNA cleavage characteristics can be used for pathogen detection, elimination of drug-resistant bacteria and genes, and hold promise as a new strategy for clinical diagnosis and treatment.

CRISPR/Cas system  /  gene editing  /  bacteria  /  drug resistance  /  treatment
Zong-ti SUN, Lang SUN, Xue-fu YOU. Current advances of CRISPR/Cas system in antibacterial field[J]. Acta Pharmaceutica Sinica, 2023 , 58 (9) : 2560 -2568 . DOI: 10.16438/j.0513-4870.2023-0235
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Year 2023 volume 58 Issue 9
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doi: 10.16438/j.0513-4870.2023-0235
  • Receive Date：2023-02-28
  • Online Date：2025-11-21
  • Published：2023-09-12
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  • Received：2023-02-28
  • Revised：2023-04-12
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    Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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