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Inhibitory effect of chikusetsusaponin IVa on proliferation of triple negative breast cancer cells
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Chen LIANG1, Ying ZHOU2, Chang-chang FAN1, Ding XU2, Qi WU2, Ruo-lan HUANG2, Yao XU1, *, Ying LUO1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(9) : 2677 - 2684
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Acta Pharmaceutica Sinica | 2023, 58(9): 2677-2684
Inhibitory effect of chikusetsusaponin IVa on proliferation of triple negative breast cancer cells
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Chen LIANG1, Ying ZHOU2, Chang-chang FAN1, Ding XU2, Qi WU2, Ruo-lan HUANG2, Yao XU1, *, Ying LUO1, 2, *
Affiliations
  • 1. Wuhan University of Science and Technology, College of Life Sciences and Health, Wuhan 430065, China
  • 2. Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, College of Biological and Food Engineering, Enshi 445000, China
Published: 2023-09-12 doi: 10.16438/j.0513-4870.2022-1313
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Chikusetsusaponin IVa (CsIVa) is a natural active monomer of triterpene saponins in the Chinese herbal medicine of Panax japonicus, which has anti-inflammatory, anti-tumor and other effects. However, its function and mechanism in triple negative breast cancer (TNBC) remain unclear. This study investigated the inhibitory effect and mechanisms of CsIVa on the proliferation of triple negative breast cancer cell line MDA-MB-231. In this study, we found that CsIVa could significantly inhibit the proliferation of MDA-MB-231 cells and eliminate its potential toxic effect on normal breast cells (MCF-10A). The transcriptome sequencing results showed that the inhibition of proliferation of MDA-MB-231 cells by CsIVa was closely related to cell cycle and the pathway regulating cell cycle. Further studies confirmed that CsIVa blocked the cell cycle in G2/M phase by down-regulating the expression of cyclin dependent kinase 1 (CDK1), cyclin B1 and up-regulating the expression of cyclin dependent kinase inhibitor 1A (p21). Moreover, CsIVa can block cell cycle through inhibiting PI3K/AKT signal pathway. In conclusion, CsIVa regulates the expression of cell cycle related proteins (p21, CDK1, cyclin B1) via inhibiting the activity of PI3K/AKT signaling pathway, blocks TNBC cell cycle, and thus exerts its anti-tumor activity.

chikusetsusaponin IVa  /  triple negative breast cancer  /  cell proliferation  /  cell cycle  /  PI3K/AKT signaling pathway
Chen LIANG, Ying ZHOU, Chang-chang FAN, Ding XU, Qi WU, Ruo-lan HUANG, Yao XU, Ying LUO. Inhibitory effect of chikusetsusaponin IVa on proliferation of triple negative breast cancer cells[J]. Acta Pharmaceutica Sinica, 2023 , 58 (9) : 2677 -2684 . DOI: 10.16438/j.0513-4870.2022-1313
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Article Info
doi: 10.16438/j.0513-4870.2022-1313
  • Receive Date：2022-12-01
  • Online Date：2025-11-21
  • Published：2023-09-12
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History
  • Received：2022-12-01
  • Revised：2023-03-26
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Affiliations
    1. Wuhan University of Science and Technology, College of Life Sciences and Health, Wuhan 430065, China
    2. Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, College of Biological and Food Engineering, Enshi 445000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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