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In vivo delivery process and regulating mechanisms of lipid-based nanomedicines
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Tian-hao DING1, Er-can WU2, Chang-you ZHAN1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(8) : 2283 - 2291
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Acta Pharmaceutica Sinica | 2023, 58(8): 2283-2291
In vivo delivery process and regulating mechanisms of lipid-based nanomedicines
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Tian-hao DING1, Er-can WU2, Chang-you ZHAN1, 2, *
Affiliations
  • 1. School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
  • 2. School of Pharmacy, Fudan University, Shanghai 201203, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0453
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Lipid-based nanocarrier is a classic drug delivery system with great biocompatibility and biodegradability. It can effectively reduce the toxicity of anti-tumor and anti-infective drugs in clinical practice. However, it has not yet met the clinical demand for enhanced therapeutic efficacy, and the clinical application is still very limited. The complex in vivo delivery process of lipid-based nanomedicine and the reciprocal interactions with body lead to unexpected changes in in vivo performance of nanomedicine and seriously hinder clinical translation. Therefore, the in-depth study of the relationships among intrinsic properties of lipid-based nanomedicine, the in vivo delivery process, and the regulatory mechanisms will not only provide guidance for the rational design of nanocarriers, but also promote the clinical translation and precision medicine of new lipid-based nanomedicine. In this review, we summarize the in vivo delivery process, regulating factors and intervention strategies for the in vivo delivery of lipid-based nanomedicine.

lipid-based nanomedicine  /  in vivo delivery process  /  protein corona  /  regulatory mechanism  /  intervention strategy
Tian-hao DING, Er-can WU, Chang-you ZHAN. In vivo delivery process and regulating mechanisms of lipid-based nanomedicines[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2283 -2291 . DOI: 10.16438/j.0513-4870.2023-0453
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Year 2023 volume 58 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2023-0453
  • Receive Date：2023-04-11
  • Online Date：2025-11-21
  • Published：2023-08-12
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  • Received：2023-04-11
  • Revised：2023-06-14
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    1. School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
    2. School of Pharmacy, Fudan University, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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