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Recent progress in delivery systems for photosensitizers and anti-cancer photodynamic therapy
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Qin-li TONG1, 2, Meng-ting CHEN1, Hong-zheng LIN1, 2, Qun-xian CHENG1, Wei LU1, 2, *, Ling XU1, *
Acta Pharmaceutica Sinica | 2023, 58(8) : 2320 - 2333
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Acta Pharmaceutica Sinica | 2023, 58(8): 2320-2333
Recent progress in delivery systems for photosensitizers and anti-cancer photodynamic therapy
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Qin-li TONG1, 2, Meng-ting CHEN1, Hong-zheng LIN1, 2, Qun-xian CHENG1, Wei LU1, 2, *, Ling XU1, *
Affiliations
  • 1. Minhang Hospital, Fudan University, Shanghai 201199, China
  • 2. School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0503
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Photodynamic therapy (PDT) is a new modality for cancer therapy, which has been used in the clinical treatment for various tumors, such as skin cancer, bladder cancer and prostate cancer. Most photosensitizers have the disadvantages of hydrophobic, low bioavailability and the limited tumor targeting ability. The nanoscale delivery systems can improve the solubility of photosensitizers and enhance their accumulation at the tumor sites. The multifunctional nano-delivery systems are prepared in combination with other anti-tumor drugs to enhance the anti-tumor effect. In addition to addressing the issues of poor solubility and the insufficient tumor targeting ability, the nanoscale delivery systems need to improve the pharmacokinetic properties of photosensitizers, facilitating their rapid accumulation at the tumor sites and quick elimination in vivo, and reducing the skin phototoxicity. This review summarizes the recent clinical application of PDT of cancer, the development of photosensitizers, the delivery systems for photosensitizers and the combinatorial application with other therapeutic methods. The goal is to present an understanding of knowledge on the design of new types of photosensitizers and its clinical application in PDT of cancer.

nanoscale delivery system  /  photosensitizer  /  photodynamic therapy  /  clinical application  /  combinatorial therapy
Qin-li TONG, Meng-ting CHEN, Hong-zheng LIN, Qun-xian CHENG, Wei LU, Ling XU. Recent progress in delivery systems for photosensitizers and anti-cancer photodynamic therapy[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2320 -2333 . DOI: 10.16438/j.0513-4870.2023-0503
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Year 2023 volume 58 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2023-0503
  • Receive Date：2023-04-24
  • Online Date：2025-11-21
  • Published：2023-08-12
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History
  • Received：2023-04-24
  • Revised：2023-07-01
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Affiliations
    1. Minhang Hospital, Fudan University, Shanghai 201199, China
    2. School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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小菇属 Mycena 11 5.26
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红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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