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Monoterpenes from an aqueous extract of the Angelica sinensis root head
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Zhao XIA1, You-zhe CHEN1, Xiao-qiang LEI1, Wei-ping LI2, Rong LIU2, Qing-lan GUO1, *, Jian-gong SHI1, *
Acta Pharmaceutica Sinica | 2023, 58(6) : 1641 - 1649
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Acta Pharmaceutica Sinica | 2023, 58(6): 1641-1649
• Original Articles •
Monoterpenes from an aqueous extract of the Angelica sinensis root head
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Zhao XIA1, You-zhe CHEN1, Xiao-qiang LEI1, Wei-ping LI2, Rong LIU2, Qing-lan GUO1, *, Jian-gong SHI1, *
Affiliations
  • 1. Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Gansu Provincial Laboratory of Fine Chemicals, Gansu Chemical Industry Research Institute Co., Ltd., Lanzhou 620100, China
Published: 2023-06-12 doi: 10.16438/j.0513-4870.2022-1425
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Eleven monoterpenes including seven new chemical structures or new natural products covering two pairs of scalemic enantiomers, together with four known analogues, were isolated from an aqueous extract of the Angelica sinensis root head (Guitou) by separation techniques of column chromatography over macroporous adsorbent resin, MCI resin, silica gel, Sephadex LH-20, and Toyopearl HW-40C, together with preparative thin-layer chromatography as well as reversed phase and chiral HPLC. Their structures were determined by spectroscopic data analysis, combined with theoretic calculation of electronic circular dichroism (ECD) spectra and single crystal X-ray diffraction. The new structures or new natural products named (+)-/(-)-angelinones A and B [(+)-/(-)-1 and (+)-/(-)-2], angelinones C and D (3 and 4), and angelinol A (5), respectively, while the known analogues were 6β, 9-dihydroxy-(+)-α-pinene (6), 1, 1, 5-trimethyl-2-hydroxymethyl-cyclohexa-2, 5-dien-4-one (7), jasminol E (8), and (+)-trans-sobrerol (9). All the isolates were reported in this plant for the first time, except for the previously reported 6 from an ethanol extract of the aerial parts of A. sinensis, of which the structure was confirmed by X-ray crystallography in this study.

Umbelliferae  /  Angelica  /  Angelica sinensis root head  /  aqueous extract  /  monoterpene  /  angelinone  /  angelinol
Zhao XIA, You-zhe CHEN, Xiao-qiang LEI, Wei-ping LI, Rong LIU, Qing-lan GUO, Jian-gong SHI. Monoterpenes from an aqueous extract of the Angelica sinensis root head[J]. Acta Pharmaceutica Sinica, 2023 , 58 (6) : 1641 -1649 . DOI: 10.16438/j.0513-4870.2022-1425
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Year 2023 volume 58 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2022-1425
  • Receive Date：2022-12-27
  • Online Date：2025-11-21
  • Published：2023-06-12
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History
  • Received：2022-12-27
  • Revised：2023-01-11
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Affiliations
    1. Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Gansu Provincial Laboratory of Fine Chemicals, Gansu Chemical Industry Research Institute Co., Ltd., Lanzhou 620100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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