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Research progress on ferroptosis regulated by glycolysis-fatty acid metabolism in metabolic diseases
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Xiao-man JIANG1, Ran DENG2, Yi WEI1, Shi-lin XIA1, Jing XU1, Ya LI1, Hong WU1, *
Acta Pharmaceutica Sinica | 2023, 58(5) : 1204 - 1210
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Acta Pharmaceutica Sinica | 2023, 58(5): 1204-1210
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Research progress on ferroptosis regulated by glycolysis-fatty acid metabolism in metabolic diseases
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Xiao-man JIANG1, Ran DENG2, Yi WEI1, Shi-lin XIA1, Jing XU1, Ya LI1, Hong WU1, *
Affiliations
  • 1. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin′an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
  • 2. School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
Published: 2023-05-12 doi: 10.16438/j.0513-4870.2022-1339
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In metabolic diseases, the accumulation of reactive oxygen species and oxidative stress are closely associated with ferroptosis. As a key regulatory factor, the imbalance between glycolysis and fatty acid metabolism can participate in ferroptosis directly or indirectly, thereby regulating the occurrence and development of various metabolic diseases. The essence of ferroptosis is a new regulatory cell death mode, which is caused by the excessive accumulation of iron-dependent lipid peroxide. It is closely related to glycolysis and fatty acid metabolism, which plays an important role in metabolic diseases. This regulatory cell death mode is significantly distinguished from other programmed cell death modes and has unique changes in cell morphology, symbolic characteristics and mechanisms. This paper first illustrates the main mechanism of glycolysis and fatty acid metabolism imbalance in the occurrence of ferroptosis, then reviews the research progress of ferroptosis in tumor, diabetes, rheumatoid arthritis and other metabolic diseases, and finally reveals the internal connection between glycolysis-fatty acid metabolism imbalance and ferroptosis, as well as its impacts on metabolic diseases, which provide new strategies for the prevention and treatment of metabolic diseases.

ferroptosis  /  glycolysis  /  fatty acid metabolism  /  metabolic disease  /  lipid peroxidation
Xiao-man JIANG, Ran DENG, Yi WEI, Shi-lin XIA, Jing XU, Ya LI, Hong WU. Research progress on ferroptosis regulated by glycolysis-fatty acid metabolism in metabolic diseases[J]. Acta Pharmaceutica Sinica, 2023 , 58 (5) : 1204 -1210 . DOI: 10.16438/j.0513-4870.2022-1339
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doi: 10.16438/j.0513-4870.2022-1339
  • Receive Date：2022-12-05
  • Online Date：2025-11-21
  • Published：2023-05-12
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History
  • Received：2022-12-05
  • Revised：2023-01-13
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Affiliations
    1. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin′an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
    2. School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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