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Research advances in the study of anticoagulant active molecules
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Kang-jia SHENG1, 2, Yan GAO1, 2, Tao BAO1, 2, *, Si-cen WANG1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(5) : 1103 - 1116
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Acta Pharmaceutica Sinica | 2023, 58(5): 1103-1116
• Special Reports: Active Ingredients and Mechanism of Action of Traditional Chinese Medicine •
Research advances in the study of anticoagulant active molecules
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Kang-jia SHENG1, 2, Yan GAO1, 2, Tao BAO1, 2, *, Si-cen WANG1, 2, *
Affiliations
  • 1. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China
  • 2. Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China
Published: 2023-05-12 doi: 10.16438/j.0513-4870.2022-1147
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The incidence of thrombosis-induced cardiovascular diseases is increasing worldwide and poses a serious threat to human health. Three factors, slow speed of blood flow, hypercoagulable blood and vascular damage, have been considered to be causes of thrombosis. Antithrombotic drugs have been classified into three categories based on the mechanism of thrombosis, including anticoagulants, platelet inhibitors and fibrinolytics. The coagulation and anticoagulation systems have drawn increasing attention because of the important role they play in the process of thrombosis. Novel compounds with anticoagulant activity are now emerging, alleviating to some extent some of the problems associated with the clinical use of early approved thrombotic drugs, such as high bleeding risk, slow onset of action and narrow therapeutic windows. In this review, we initially describe the mechanisms of coagulation as well as thrombosis. Meanwhile, a wide range of bioactive compounds and potential antithrombotic candidates reported in recent years have been summarized. In addition, the structure-activity relationship of certain compounds has been discussed, expecting to facilitate the development of molecules with anticoagulant biological activity for the treatment of thrombotic diseases.

anticoagulant activity  /  antithrombotic activity  /  druggability evaluation  /  small molecule active substance  /  structure-activity relationship
Kang-jia SHENG, Yan GAO, Tao BAO, Si-cen WANG. Research advances in the study of anticoagulant active molecules[J]. Acta Pharmaceutica Sinica, 2023 , 58 (5) : 1103 -1116 . DOI: 10.16438/j.0513-4870.2022-1147
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Article Info
doi: 10.16438/j.0513-4870.2022-1147
  • Receive Date：2022-10-28
  • Online Date：2025-11-21
  • Published：2023-05-12
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History
  • Received：2022-10-28
  • Revised：2023-02-15
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Affiliations
    1. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China
    2. Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China
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