Home Journals Articles Updates About
CN
image
收藏切换
Research progress on the development of human neutrophil elastase inhibitors
收藏切换
PDF
Zhong-wei WANG, Hui WEN, Yu-chen WANG, Hua-qing CUI*
Acta Pharmaceutica Sinica | 2023, 58(4) : 909 - 918
Less
收藏切换
Acta Pharmaceutica Sinica | 2023, 58(4): 909-918
Research progress on the development of human neutrophil elastase inhibitors
Full
Zhong-wei WANG, Hui WEN, Yu-chen WANG, Hua-qing CUI*
Affiliations
  • Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1116
Outline
收藏切换

Human neutrophil elastase (hNE) is a serine proteolytic enzyme mainly distributed in neutrophils. When the balance between anti-hNE protein and hNE is broken, excessive release of hNE can cause the occurrence of various diseases. Therefore, inhibition of hNE is a promising therapeutic strategy. In this paper, the structure, action mechanism, physiological function of hNE and the development of hNE inhibitors were briefly summarized, in order to provide information for the related research.

human neutrophil elastase  /  human neutrophil elastase mechanism  /  human neutrophil elastase physiological effect  /  human neutrophil elastase inhibitor
Zhong-wei WANG, Hui WEN, Yu-chen WANG, Hua-qing CUI. Research progress on the development of human neutrophil elastase inhibitors[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 909 -918 . DOI: 10.16438/j.0513-4870.2022-1116
Appendix
Less
Year 2023 volume 58 Issue 4
PDF
169
78
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-1116
  • Receive Date：2022-10-17
  • Online Date：2025-11-21
  • Published：2023-04-12
Article Data
Affiliations
History
  • Received：2022-10-17
  • Revised：2022-12-09
Funding
Affiliations
    Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-1116
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House