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Advances in research of heart organoid and its application in drug discovery
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Di WU1, 2, Shou-bao WANG1, *, Guan-hua DU1, *
Acta Pharmaceutica Sinica | 2023, 58(4) : 884 - 890
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Acta Pharmaceutica Sinica | 2023, 58(4): 884-890
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Advances in research of heart organoid and its application in drug discovery
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Di WU1, 2, Shou-bao WANG1, *, Guan-hua DU1, *
Affiliations
  • 1. Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai 264005, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1175
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Cardiovascular diseases are fatal threats to human health and also important fields in drug discovery. Organoid is a miniature with the structure and function similar to the organ, which is formed by the self-updating and specific differentiation of stem cells during the in vitro culture. Considering its characteristics of human origin, physical features, self-assembling and genetic stability, heart organoid has attracted much attention in the study of cardiogenesis, cardiovascular diseases modeling and related drug research. Hence, this article will review the development of heart organoids and its construction strategies, highlighting its application and prospects in drug discovery.

heart organoid  /  induced-pluripotent stem cell  /  disease model  /  organoids on chip  /  drug screening  /  drug evaluation
Di WU, Shou-bao WANG, Guan-hua DU. Advances in research of heart organoid and its application in drug discovery[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 884 -890 . DOI: 10.16438/j.0513-4870.2022-1175
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Year 2023 volume 58 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2022-1175
  • Receive Date：2022-11-03
  • Online Date：2025-11-21
  • Published：2023-04-12
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History
  • Received：2022-11-03
  • Revised：2022-12-20
Funding
Affiliations
    1. Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai 264005, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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