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Dimeric phthalides from an aqueous extract of the Angelica sinensis root head
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Zhao XIA, You-zhe CHEN, Cheng-bo XU, Cheng-gen ZHU, Xiao-qiang LEI, Qing-lan GUO*, Jian-gong SHI*
Acta Pharmaceutica Sinica | 2023, 58(4) : 975 - 991
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Acta Pharmaceutica Sinica | 2023, 58(4): 975-991
• Original Articles •
Dimeric phthalides from an aqueous extract of the Angelica sinensis root head
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Zhao XIA, You-zhe CHEN, Cheng-bo XU, Cheng-gen ZHU, Xiao-qiang LEI, Qing-lan GUO*, Jian-gong SHI*
Affiliations
  • Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1257
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Ten dimeric phthalide racemates (1-10) were isolated from an aqueous extract of the Angelica sinensis root head (Guitou) by separation techniques of column chromatography over macroporous adsorbent resin, MCI resin, silica gel, and Sephadex LH-20, together with preparative thin-layer chromatography and reversed phase HPLC. The racemates were further separated into (+)-/(-)-1-(+)-/(-)-10 with chiral HPLC. Their structures including absolute configurations were elucidated by comprehensive analysis of spectroscopic data, combined with electronic circular dichroism (ECD) and NMR calculations as well as single crystal X-ray diffractions. Compounds (+)-/(-)-1-(+)-/(-)-10 are either new structure or new natural product, named (+)-/(-)-angelidipthalidic acids A-H [(+)-/(-)-1-(+)-/(-)-8] and (+)-/(-)-angelidipthalidols A and B [(+)-/(-)-9 and (+)-/(-)-10], respectively. Meanwhile, dimeric phthalide mono- and bis-lactone derivatives with 3.3′a, 8.6′- and 3.6′, 8.3′a-coupling patterns as well as determination of their relative configurations are discussed.

Umbelliferae  /  Angelica  /  Angelica sinensis root head  /  aqueous extract  /  dimeric phthalide  /  angelidipthalidic acid  /  angelidipthalidol
Zhao XIA, You-zhe CHEN, Cheng-bo XU, Cheng-gen ZHU, Xiao-qiang LEI, Qing-lan GUO, Jian-gong SHI. Dimeric phthalides from an aqueous extract of the Angelica sinensis root head[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 975 -991 . DOI: 10.16438/j.0513-4870.2022-1257
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doi: 10.16438/j.0513-4870.2022-1257
  • Receive Date：2022-11-22
  • Online Date：2025-11-21
  • Published：2023-04-12
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  • Received：2022-11-22
  • Revised：2022-12-13
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    Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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