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Evaluation of the physicochemical properties of alkali-soluble polysaccharide from Poria and its application in diclofenac sodium sustained-release tablets
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Rong MAO1, Wen-you FANG1, Juan SUN1, Song GAO1, Jun-ling LIU2, Sheng-qi CHEN1, 3, Rong-feng HU1, 4, 5, *, Qing-lin LI1, 3, *
Acta Pharmaceutica Sinica | 2023, 58(4) : 1033 - 1040
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Acta Pharmaceutica Sinica | 2023, 58(4): 1033-1040
• Original Articles •
Evaluation of the physicochemical properties of alkali-soluble polysaccharide from Poria and its application in diclofenac sodium sustained-release tablets
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Rong MAO1, Wen-you FANG1, Juan SUN1, Song GAO1, Jun-ling LIU2, Sheng-qi CHEN1, 3, Rong-feng HU1, 4, 5, *, Qing-lin LI1, 3, *
Affiliations
  • 1. Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Anhui University of Chinese Medicine, Hefei 230012, China
  • 2. Anhui Food and Drug Inspection and Research Institute; Hefei 230051, China
  • 3. Key Laboratory of Xin'an Medicine, the Ministry of Education, Anhui University of Chinese Medicine, Hefei 230038, China
  • 4. MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei 230012, China
  • 5. Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei 230012, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1032
Outline
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In this study, alkali-soluble polysaccharide was extracted from Poria residue, and the structure of alkali-soluble polysaccharide was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), and differential scanning calorimetry (DSC). The physical morphology of alkali-soluble polysaccharide and ethyl cellulose (EC) was investigated by scanning electron microscopy (SEM), and the focus on angle of repose, bulk density, tapped density, Carr index, interparticle porosity, cohesion index, Hausner ratio, etc. The physical fingerprints were drawn, and the powder properties were evaluated by multivariate analysis. Diclofenac sodium extended-release tablets were prepared by direct compression method using alkali-soluble polysaccharide and EC as insoluble backbone materials to evaluate the basic properties of the extended-release tablets, investigate the in vitro drug release behavior and study the release mechanism. The results showed that alkali-soluble polysaccharide is a semi-crystalline polymer with smooth lamellar structure, and its stacking and compressibility are stronger than EC. The in vitro release experiments showed that the slow release performance of alkali-soluble polysaccharide is stronger than EC, and the release behavior of the prepared slow release tablets is in accordance with the Higuchi model. The pore structure is formed inside the tablets during the release process, and the release mode is pore diffusion release. The results of this study are of great significance for the development of new slow-release materials and the rational use of resources.

Poria  /  polysaccharide  /  ethyl cellulose  /  characterization  /  micromeritic property  /  drug release
Rong MAO, Wen-you FANG, Juan SUN, Song GAO, Jun-ling LIU, Sheng-qi CHEN, Rong-feng HU, Qing-lin LI. Evaluation of the physicochemical properties of alkali-soluble polysaccharide from Poria and its application in diclofenac sodium sustained-release tablets[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 1033 -1040 . DOI: 10.16438/j.0513-4870.2022-1032
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Year 2023 volume 58 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2022-1032
  • Receive Date：2022-08-30
  • Online Date：2025-11-21
  • Published：2023-04-12
Article Data
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History
  • Received：2022-08-30
  • Revised：2022-09-25
Funding
Affiliations
    1. Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Anhui University of Chinese Medicine, Hefei 230012, China
    2. Anhui Food and Drug Inspection and Research Institute; Hefei 230051, China
    3. Key Laboratory of Xin'an Medicine, the Ministry of Education, Anhui University of Chinese Medicine, Hefei 230038, China
    4. MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei 230012, China
    5. Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei 230012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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