Home Journals Articles Updates About
CN
image
收藏切换
Research progress of cyclic peptide synthesis strategy and its application in new drug development
收藏切换
PDF
Si-jia SU1, Qing-wei BU1, Chun-quan SHENG1, 2, *, Shan-chao WU2, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 629 - 638
Less
收藏切换
Acta Pharmaceutica Sinica | 2023, 58(3): 629-638
• Reviews •
Research progress of cyclic peptide synthesis strategy and its application in new drug development
Full
Si-jia SU1, Qing-wei BU1, Chun-quan SHENG1, 2, *, Shan-chao WU2, *
Affiliations
  • 1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
  • 2. Second Military Medical University, Shanghai 200433, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-0956
Outline
收藏切换

Protein-protein interaction (PPI) plays an important role in the regulation of life. Most of the PPI interfaces are large and discontinuous, and it is difficult for small molecules to specifically bind to them. Peptides are critical in PPI surface interactions due to their higher affinity and specificity. However, peptides have some defects such as easy hydrolysis by protease and poor membrane permeability. Due to good biocompatibility and chemical diversity, cyclic peptides play an important role in drug discovery. Therefore, the development of efficient cyclic peptide construction methods has become a frontier issue in peptide drug research. In recent years, a series of new progresses have been made in the synthesis strategy and the application of cyclic peptides, providing powerful technical tools for the research and development of cyclic peptide drugs. In this review, the synthesis strategies of cyclic peptides and their application will be reviewed from four aspects: synthesis strategies, property improvement, biological activity and prospect.

peptide  /  cyclic peptide  /  synthetic strategy  /  improve property  /  biological activity
Si-jia SU, Qing-wei BU, Chun-quan SHENG, Shan-chao WU. Research progress of cyclic peptide synthesis strategy and its application in new drug development[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 629 -638 . DOI: 10.16438/j.0513-4870.2022-0956
Appendix
Less
Year 2023 volume 58 Issue 3
PDF
240
110
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0956
  • Receive Date：2022-08-03
  • Online Date：2025-11-21
  • Published：2023-03-12
Article Data
Affiliations
History
  • Received：2022-08-03
  • Revised：2022-09-13
Funding
Affiliations
    1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
    2. Second Military Medical University, Shanghai 200433, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0956
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House