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Research progress on pathogenesis and treatment of drug-resistant epilepsy
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Cheng-hao XU1, Peng-cheng WU1, Tong-min HUANG1, Hai-mei LU2, Zheng-hao XU2, 3, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 581 - 592
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Acta Pharmaceutica Sinica | 2023, 58(3): 581-592
Research progress on pathogenesis and treatment of drug-resistant epilepsy
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Cheng-hao XU1, Peng-cheng WU1, Tong-min HUANG1, Hai-mei LU2, Zheng-hao XU2, 3, *
Affiliations
  • 1. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • 2. School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • 3. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Hangzhou 310053, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-1096
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Epilepsy is a chronic nervous system disease, which affects more than 70 million people all over the world. Although more than 30 kinds of antiepileptic drugs (AEDs) have been on the market, about one third of the patients with epilepsy fail to respond to medical treatment, who become drug-resistant epilepsy patients. Identifying the mechanism and developing effective treatment methods for drug-resistant epilepsy have become a hot area in the field of epilepsy research. This review discussed resent advance on the pathogenesis of drug-resistant epilepsy from the transporter hypothesis, neural network hypothesis and target hypothesis, and we also summarized the existing potential treatment methods and research progress of drug-resistant epilepsy, such as surgical resection, deep brain stimulation, ketogenic diet, precise treatment, and traditional Chinese medicine treatment. Our review may provide useful clues for the mechanisms research and clinical treatments of drug-resistant epilepsy.

drug-resistant epilepsy  /  pathogenesis  /  precise treatment  /  ketogenic diet  /  traditional Chinese medicine treatment
Cheng-hao XU, Peng-cheng WU, Tong-min HUANG, Hai-mei LU, Zheng-hao XU. Research progress on pathogenesis and treatment of drug-resistant epilepsy[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 581 -592 . DOI: 10.16438/j.0513-4870.2022-1096
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Year 2023 volume 58 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2022-1096
  • Receive Date：2022-10-07
  • Online Date：2025-11-21
  • Published：2023-03-12
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History
  • Received：2022-10-07
  • Revised：2022-11-04
Funding
Affiliations
    1. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
    2. School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
    3. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Hangzhou 310053, China
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