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Research progress of sphingosine kinase and sphingosine-1-phosphate (S1P)/S1P receptor signaling in tumor microenvironment
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Xi-hua WEI, Ze-qun WANG, Jing-jing CHEN, Yan PAN*
Acta Pharmaceutica Sinica | 2023, 58(3) : 571 - 580
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Acta Pharmaceutica Sinica | 2023, 58(3): 571-580
Research progress of sphingosine kinase and sphingosine-1-phosphate (S1P)/S1P receptor signaling in tumor microenvironment
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Xi-hua WEI, Ze-qun WANG, Jing-jing CHEN, Yan PAN*
Affiliations
  • School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-1042
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Sphingosine kinase (SphK), sphingosine-1-phosphate (S1P) and S1P receptor (S1PR) are involved in the tumor biological processes such as tumor cell proliferation and migration, and play an important role in the development of cancer. In recent years, researchers have increasingly focused on the interaction between cancer cells and the tumor microenvironment. The tumor microenvironment is genetically stable and can be induced to an antitumor phenotype, which has significant therapeutic advantages. Studies have shown that SphK/S1P/S1PR can regulate multiple aspects of the tumor microenvironment. This review summarizes the effects of SphK and S1P/S1PR signaling on the tumor microenvironment from four perspectives: tumor immune microenvironment, cancer associated fibroblasts, tumor angiogenesis and tumor hypoxic microenvironment, and also outlines potential drug research related to these signal molecules, aiming to elucidate the role of SphK/S1P/S1PR in tumor occurrence and development and provide new ideas for the research of anti-tumor drugs.

tumor microenvironment  /  sphingosine kinase  /  sphingosine-1-phosphate  /  sphingosine 1-phosphate receptor  /  anti-tumor drug
Xi-hua WEI, Ze-qun WANG, Jing-jing CHEN, Yan PAN. Research progress of sphingosine kinase and sphingosine-1-phosphate (S1P)/S1P receptor signaling in tumor microenvironment[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 571 -580 . DOI: 10.16438/j.0513-4870.2022-1042
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doi: 10.16438/j.0513-4870.2022-1042
  • Receive Date：2022-09-06
  • Online Date：2025-11-21
  • Published：2023-03-12
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  • Received：2022-09-06
  • Revised：2022-11-14
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    School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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