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Short chain fatty acid: a messenger of gut-organ axis for disease regulation
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Hui-hui GUO1, Hao-ran SHEN1, Yan-xing HAN1, Jian-dong JIANG1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 593 - 604
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Acta Pharmaceutica Sinica | 2023, 58(3): 593-604
Short chain fatty acid: a messenger of gut-organ axis for disease regulation
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Hui-hui GUO1, Hao-ran SHEN1, Yan-xing HAN1, Jian-dong JIANG1, 2, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-1134
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Gut microbiota is a complex and dynamic system, and is essential for the health of the body. As the "second genome" of the body, it can establish communication with the important organs by regulating intestinal nerves, gastrointestinal hormones, intestinal barrier, immunity and metabolism, thus affecting host′s physiological functions. Short chain fatty acid (SCFA), known as one important metabolite of intestinal microbiota, is regarded as a significant messenger of the gut-organ communication, due to its extensive regulation in the body′s immunity, metabolism, endocrine and signal transduction. In this review, we summarize the interaction between gut-liver/brain/kidney/lung axis and diseases, and focus on the role and mechanism of SCFA in the gut-organ communication, hoping to provide new ideas for the treatment of the related diseases.

short chain fatty acid  /  gut-organ axis  /  gut microbiota  /  immuno-inflammation  /  endocrine  /  signal transduction
Hui-hui GUO, Hao-ran SHEN, Yan-xing HAN, Jian-dong JIANG. Short chain fatty acid: a messenger of gut-organ axis for disease regulation[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 593 -604 . DOI: 10.16438/j.0513-4870.2022-1134
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Article Info
doi: 10.16438/j.0513-4870.2022-1134
  • Receive Date：2022-10-28
  • Online Date：2025-11-21
  • Published：2023-03-12
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History
  • Received：2022-10-28
  • Revised：2022-11-18
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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