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Research progress of intelligent reversible drug delivery system
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Ke-xin CONG1, Xiao-dan SONG1, Ya-nan SUN1, Chao-xing HE1, Shao-kun YANG1, De-ying CAO1, Jing BAI2, Jia ZHANG3, *, Bai XIANG1, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 483 - 493
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Acta Pharmaceutica Sinica | 2023, 58(3): 483-493
• Special Reports: Research on Precise Treatment of Diseases Based on Smart Drug Delivery Systems •
Research progress of intelligent reversible drug delivery system
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Ke-xin CONG1, Xiao-dan SONG1, Ya-nan SUN1, Chao-xing HE1, Shao-kun YANG1, De-ying CAO1, Jing BAI2, Jia ZHANG3, *, Bai XIANG1, *
Affiliations
  • 1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2. The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • 3. The Fourth Hospital of Shijiazhuang, Shijiazhuang 050035, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-0596
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In the research on cancer theranostics, most environment-sensitive drug delivery systems can only achieve unidirectional and irreversible responsive changes under pathological conditions, thereby improving the targeting effect and drug release performance of the delivery system. However, such irreversible changes pose potential safety hazards when the dynamically distributed delivery system returns to the blood circulation or transports to the normal physiological environment. Intelligent reversible drug delivery systems can respond to normal physiological and pathological microenvironments to achieve bidirectional and reversible structural changes. This feature will help to precisely control the drug release of the delivery system, prolong the blood circulation time, improve the targeting efficiency, and avoid the potential safety hazards of the irreversible drug delivery system. In this review, we describe the research progress of intelligent reversible drug delivery system from two main aspects: controlled drug release and prolonged blood circulation time/enhanced cellular internalization of drug.

cancer theranostics  /  reversible  /  drug delivery system  /  nanocarrier  /  controlled release
Ke-xin CONG, Xiao-dan SONG, Ya-nan SUN, Chao-xing HE, Shao-kun YANG, De-ying CAO, Jing BAI, Jia ZHANG, Bai XIANG. Research progress of intelligent reversible drug delivery system[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 483 -493 . DOI: 10.16438/j.0513-4870.2022-0596
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Article Info
doi: 10.16438/j.0513-4870.2022-0596
  • Receive Date：2022-05-16
  • Online Date：2025-11-21
  • Published：2023-03-12
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History
  • Received：2022-05-16
  • Revised：2022-08-01
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Affiliations
    1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2. The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
    3. The Fourth Hospital of Shijiazhuang, Shijiazhuang 050035, China
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