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Research progress on multi-target regulation strategies of tumor microenvironment based on nano-drug delivery system
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Jing LI1, 2, Ting PAN1, 2, Si-yao ZHAO1, 2, Xiao-qing CHEN1, 2, Hao-tian YIN1, 2, Xiao-ye JI1, 2, Qi-fan WU1, 2, Wei WANG1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 536 - 549
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Acta Pharmaceutica Sinica | 2023, 58(3): 536-549
Research progress on multi-target regulation strategies of tumor microenvironment based on nano-drug delivery system
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Jing LI1, 2, Ting PAN1, 2, Si-yao ZHAO1, 2, Xiao-qing CHEN1, 2, Hao-tian YIN1, 2, Xiao-ye JI1, 2, Qi-fan WU1, 2, Wei WANG1, 2, *
Affiliations
  • 1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210098, China
  • 2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210098, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-0939
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Tumor microenvironment (TME) is composed of endothelial cells, pericytes, immune cells, cancer-associated fibroblasts (CAFs), cancer stem cells (CSCs), extracellular matrix (ECM) and other components of the complex biological environment. TME interacts with the tumor cells through a large amount of signaling pathways, participates in the process of tumor progression, invasion, and metastasis. Hence, TME has become a potential therapeutic target for cancer treatment, exhibiting excellent therapeutic potential and research value in the field of cancer treatment. Currently, the novel nanotechnology has been widely applied in anticancer therapy, and nanotechnology-mediated drug delivery system is being explored to apply in TME modulation to inhibit tumor progression. Nanotechnology-mediated drug delivery has many advantages over traditional therapeutic modalities, including longer circulation times, improved bioavailability, and reduced toxicity. This review summarized the research of targeted nano-drug delivery based on TME regulation, including regulation strategies based on CSCs, CAFs, immune cells, ECM, tumor vascularization, exosomes, and microbiota. In addition, we summarized the advantages, opportunities, and challenges of TME regulation strategy compared with traditional treatment strategy, which provides a reference for the application of nano-drug delivery system based on TME regulation strategy in tumor precision therapy.

tumor microenvironment  /  nanotechnology  /  regulation  /  targeting  /  tumor therapy
Jing LI, Ting PAN, Si-yao ZHAO, Xiao-qing CHEN, Hao-tian YIN, Xiao-ye JI, Qi-fan WU, Wei WANG. Research progress on multi-target regulation strategies of tumor microenvironment based on nano-drug delivery system[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 536 -549 . DOI: 10.16438/j.0513-4870.2022-0939
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Article Info
doi: 10.16438/j.0513-4870.2022-0939
  • Receive Date：2022-07-31
  • Online Date：2025-11-21
  • Published：2023-03-12
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History
  • Received：2022-07-31
  • Revised：2022-09-26
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Affiliations
    1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210098, China
    2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210098, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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