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A new germacrene-type sesquiterpenoid from Elephantopus tomentosus L.
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Meng-yao ZHANG1, 2, Qiang HUANG1, 3, Hai-xin ZHANG1, Meng YU1, Tao ZHANG1, *, Zhong-mei ZOU1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 729 - 735
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Acta Pharmaceutica Sinica | 2023, 58(3): 729-735
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A new germacrene-type sesquiterpenoid from Elephantopus tomentosus L.
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Meng-yao ZHANG1, 2, Qiang HUANG1, 3, Hai-xin ZHANG1, Meng YU1, Tao ZHANG1, *, Zhong-mei ZOU1, 2, *
Affiliations
  • 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
  • 2. Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China
  • 3. Shenyang Pharmaceutical University, Shenyang 110016, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-1069
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Fifteen compounds were isolated from the 95% ethanol extract of the whole plant of Elephantopus tomentosus L. by silica gel column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography and semi-preparative HPLC methods. Their structures were identified on the basis of physicochemical properties, and spectral data (UV, IR, NMR, MS and CD) analysis as tomenlephanlide A (1), molephantinin (2), molephantin (3), 8-O-methacryloylelephanpane (4), apigenin (5), tricin (6), 2-phenyl acetamide (7), 3, 4-dihydroxybenzoic acid methyl ester (8), caffeic acid methyl ester (9), caffeic acid ethyl ester (10), (+)-(4S)-(2E)-4-hydroxy-2-nonenoic acid (11), E-4-hydroxyhex-2-enoic acid (12), 1H-indole-3-carboxylic acid (13), 1H-indole-3-carbaldehyde (14) and isohematinic acid (15). Among them, compound 1 is a new germacrene-type sesquiterpenoid, 5-15 were obtained from E. tomentosus L. for the first time. It was the first time the absolute configuration of compound 2 was reported. Compound 1 showed weak cytotoxicity against gastric cancer cells (SGC-7901).

Compositae  /  Elephantopus tomentosus L.  /  chemical constituent  /  germacrene-type sesquiterpenoid  /  cytotoxicity
Meng-yao ZHANG, Qiang HUANG, Hai-xin ZHANG, Meng YU, Tao ZHANG, Zhong-mei ZOU. A new germacrene-type sesquiterpenoid from Elephantopus tomentosus L.[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 729 -735 . DOI: 10.16438/j.0513-4870.2022-1069
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Year 2023 volume 58 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2022-1069
  • Receive Date：2022-09-21
  • Online Date：2025-11-21
  • Published：2023-03-12
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History
  • Received：2022-09-21
  • Revised：2022-10-19
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Affiliations
    1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    2. Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China
    3. Shenyang Pharmaceutical University, Shenyang 110016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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