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Application of nanotechnology in local anesthetic drug sustained release and light-responsive controlled release
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Zhi-qi WANG1, 2, Peter TIMASHEV3, Xing-Jie LIANG2, 4, *, Yong LUAN1, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 530 - 535
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Acta Pharmaceutica Sinica | 2023, 58(3): 530-535
• Special Reports: Research on Precise Treatment of Diseases Based on Smart Drug Delivery Systems •
Application of nanotechnology in local anesthetic drug sustained release and light-responsive controlled release
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Zhi-qi WANG1, 2, Peter TIMASHEV3, Xing-Jie LIANG2, 4, *, Yong LUAN1, *
Affiliations
  • 1. Department of Anesthesiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
  • 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
  • 3. Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow 119991, Russia
  • 4. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-0932
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Local anesthetic drugs are commonly used to block the conduction function of patient's nerves temporarily for anesthesia during surgery or to provide targeted analgesia after trauma. Compared with general anesthetics, local anesthetics makes less impact on the physiological status and alleviates pain complications in the presence of clear consciousness. However, its clinical application is still limited by its systemic toxicity, as well as toxicity to nerves and muscles, duration of action and lack of penetration. Nanotechnology can help it penetrate the physiological barrier, prolong the time of nerve block, and reduce toxic side effects. In addition, by building a light-responsive release system, local anesthetics can be released on demand, enhancing drug effectiveness and safety. However, in addition to the problems of poor consistency and high production costs, the system of light response release is still limited in application due to the limitation of the depth of penetration of the tissue. According to the current research progress, this paper briefly introduces and analyzes the main dosage forms, hoping to provide new ideas for the responsive release of local anesthetic drugs.

local anesthetic  /  liposome  /  polymeric  /  prodrug  /  controllable drug release
Zhi-qi WANG, Peter TIMASHEV, Xing-Jie LIANG, Yong LUAN. Application of nanotechnology in local anesthetic drug sustained release and light-responsive controlled release[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 530 -535 . DOI: 10.16438/j.0513-4870.2022-0932
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Article Info
doi: 10.16438/j.0513-4870.2022-0932
  • Receive Date：2022-07-31
  • Online Date：2025-11-21
  • Published：2023-03-12
Article Data
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History
  • Received：2022-07-31
  • Revised：2022-08-29
Funding
Affiliations
    1. Department of Anesthesiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
    2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
    3. Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow 119991, Russia
    4. University of Chinese Academy of Sciences, Beijing 100049, China
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