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Application of PDX model in the evaluation of nano-delivery systems
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Yu-meng XI1, Yu LU1, Xiao-ming HE1, Shao-kun YANG1, Jia ZHANG2, Jian-kai YANG3, Chao-xing HE1, *, Bai XIANG1, *
Acta Pharmaceutica Sinica | 2023, 58(2) : 330 - 338
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Acta Pharmaceutica Sinica | 2023, 58(2): 330-338
• Reviews •
Application of PDX model in the evaluation of nano-delivery systems
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Yu-meng XI1, Yu LU1, Xiao-ming HE1, Shao-kun YANG1, Jia ZHANG2, Jian-kai YANG3, Chao-xing HE1, *, Bai XIANG1, *
Affiliations
  • 1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2. The Fourth Hospital of Shijiazhuang, Shijiazhuang 050035, China
  • 3. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Published: 2023-02-12 doi: 10.16438/j.0513-4870.2022-0720
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Malignant tumor is a major disease affecting human health. The nano-delivery system itself has a unique size effect and it can achieve tumor-targeted distribution of drug molecules, improve the therapeutic effect, and reduce the toxic and side effects on normal tissues and cells after functional modification. Patient-derived xenografts (PDX) models can be established by transplanting patient-derived cancer cells or small tumor tissue into immunodeficient mice directly. Compared with the tumor cell line model, this model can preserve the key features of the primary tumor such as histomorphology, heterogeneity, and genetic abnormalities, and keep them stable between generations. PDX models are widely used in drug evaluation, target discovery and biomarker development, especially providing a reliable research platform for the diagnosis and treatment evaluation of nano-delivery systems. This review summarizes the application of several common cancer PDX models in the evaluation of nano-delivery systems, in order to provide references for researchers to perform related research.

nano-delivery system  /  patient-derived xenografts model  /  cancer  /  immunodeficient mouse  /  drug evaluation
Yu-meng XI, Yu LU, Xiao-ming HE, Shao-kun YANG, Jia ZHANG, Jian-kai YANG, Chao-xing HE, Bai XIANG. Application of PDX model in the evaluation of nano-delivery systems[J]. Acta Pharmaceutica Sinica, 2023 , 58 (2) : 330 -338 . DOI: 10.16438/j.0513-4870.2022-0720
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Article Info
doi: 10.16438/j.0513-4870.2022-0720
  • Receive Date：2022-06-10
  • Online Date：2025-11-21
  • Published：2023-02-12
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History
  • Received：2022-06-10
  • Revised：2022-09-01
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Affiliations
    1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2. The Fourth Hospital of Shijiazhuang, Shijiazhuang 050035, China
    3. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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