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Recent advances in small molecule inhibitors of interleukin‑1 receptor-associated kinase
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Jing-cheng YU1, Zheng-chuan DONG2, Rui-xu MU3, Le-yuan CHEN3, Yi-liang LI3, *, Wen-bin HOU3, *
Acta Pharmaceutica Sinica | 2023, 58(1) : 27 - 38
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Acta Pharmaceutica Sinica | 2023, 58(1): 27-38
• Reviews •
Recent advances in small molecule inhibitors of interleukin‑1 receptor-associated kinase
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Jing-cheng YU1, Zheng-chuan DONG2, Rui-xu MU3, Le-yuan CHEN3, Yi-liang LI3, *, Wen-bin HOU3, *
Affiliations
  • 1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2. Tianjin Chase Sun Pharmaceutical Co., Ltd., Tianjin 301700, China
  • 3. Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
Published: 2023-01-12 doi: 10.16438/j.0513-4870.2022-0695
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Interleukin-1 receptor associated kinase 4 (IRAK-4), acting as a serine threonine kinase, is considered as a key signal node for the transduction of IL-1R family and TLRs signal pathway. Studies have found that IRAK-4 has a hand in many signal pathways, involving the inflammatory response of human joints, intestines, liver and nervous system, as well as other autoimmune diseases. It is also one of the causes of drug resistance of some cancer cells. Therefore, IRAK-4 tends to be an effective therapeutic target for inflammatory diseases and cancer. The prospects for the development of drugs in this pathway is to develop novel IRAK-4 small molecule inhibitors and investigate their safety and effectiveness, enrich the clinical treatment of inflammatory and cancer diseases finally. This paper classified and summarized the latest research progress on small molecule inhibitors of IRAK-4 signaling pathway according to structures of the compounds, in order to provide assistances and references for the research and development of related drugs.

interleukin-1 receptor-associated kinase 4  /  TLRs/IL-1R signaling pathway  /  inflammatory disease  /  antitumor  /  small molecule inhibitor
Jing-cheng YU, Zheng-chuan DONG, Rui-xu MU, Le-yuan CHEN, Yi-liang LI, Wen-bin HOU. Recent advances in small molecule inhibitors of interleukin‑1 receptor-associated kinase[J]. Acta Pharmaceutica Sinica, 2023 , 58 (1) : 27 -38 . DOI: 10.16438/j.0513-4870.2022-0695
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Article Info
doi: 10.16438/j.0513-4870.2022-0695
  • Receive Date：2022-06-03
  • Online Date：2025-11-21
  • Published：2023-01-12
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  • Received：2022-06-03
  • Revised：2022-07-15
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Affiliations
    1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2. Tianjin Chase Sun Pharmaceutical Co., Ltd., Tianjin 301700, China
    3. Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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