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Research progress of cell membrane-coated biomimetic nanoparticle delivery systems for the treatment of lung diseases
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Yu-ying WANG1, 2, Xi WANG1, 2, Hong-lin QIN1, 2, Jian YANG1, 2, 3, *
Acta Pharmaceutica Sinica | 2023, 58(1) : 76 - 85
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Acta Pharmaceutica Sinica | 2023, 58(1): 76-85
Research progress of cell membrane-coated biomimetic nanoparticle delivery systems for the treatment of lung diseases
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Yu-ying WANG1, 2, Xi WANG1, 2, Hong-lin QIN1, 2, Jian YANG1, 2, 3, *
Affiliations
  • 1. State Key Laboratory of Component-based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2. Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 3. Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
Published: 2023-01-12 doi: 10.16438/j.0513-4870.2022-0559
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Lung is susceptible to external disturbance, resulting in a variety of acute and chronic lung diseases. Functionalized nanoparticles as carriers can carry drugs through multiple biological barriers of lung into lung lesions, but there are some problems such as poor targeting and low therapeutic efficiency. As a drug carrier, membrane-coated biomimetic nanoparticles have the characteristics of immune system escape, active targeting, inflammatory chemotaxis and crossing physiological barriers due to the retention of the characteristics of the source cells. Therefore, it has been widely used in the treatment of lung diseases in recent years. In this review, the application of membrane-coated biomimetic nanoparticles in the treatment of lung diseases in the recent years was summarized and classified. Cell membrane sources include erythrocyte membrane, platelet membrane, macrophage membrane, neutrophil membrane, lung epithelial membrane, lung surfactant, endothelial membrane, cancer cell membrane, bacterial membrane, hybrid membrane and so on. The purpose of this review is to provide a new idea for treating lung diseases with membrane-coated biomimetic nanoparticles.

cell membrane coated  /  biomimetic nanoparticle  /  drug delivery system  /  pulmonary disease  /  physiological barrier  /  immune escape
Yu-ying WANG, Xi WANG, Hong-lin QIN, Jian YANG. Research progress of cell membrane-coated biomimetic nanoparticle delivery systems for the treatment of lung diseases[J]. Acta Pharmaceutica Sinica, 2023 , 58 (1) : 76 -85 . DOI: 10.16438/j.0513-4870.2022-0559
Year 2023 volume 58 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2022-0559
  • Receive Date:2022-05-09
  • Online Date:2025-11-21
  • Published:2023-01-12
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  • Received:2022-05-09
  • Revised:2022-06-07
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Affiliations
    1. State Key Laboratory of Component-based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2. Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    3. Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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