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Autophagy-regulated strategies in pre-clinical studies of inflammatory bowel disease
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Wen-sheng YANG1, Wei WU1, Jing-lin WANG2, Guang-fei WANG1, Zhi-ping LI1, *
Acta Pharmaceutica Sinica | 2023, 58(1) : 1 - 8
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Acta Pharmaceutica Sinica | 2023, 58(1): 1-8
Autophagy-regulated strategies in pre-clinical studies of inflammatory bowel disease
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Wen-sheng YANG1, Wei WU1, Jing-lin WANG2, Guang-fei WANG1, Zhi-ping LI1, *
Affiliations
  • 1. Department of Pharmacy, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China
  • 2. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Published: 2023-01-12 doi: 10.16438/j.0513-4870.2022-0836
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Inflammatory bowel disease (IBD) is a group of chronic idiopathic colorectal inflammatory diseases with a progressive and unpredictable course, including ulcerative colitis (UC) and Crohn's disease (CD). Abnormal intestinal inflammation and immune response contribute to the pathogenesis of IBD. Autophagy as an essential catabolic process in cells, has been demonstrated to have associations with a variety of inflammatory diseases including IBD. Here, we review the relationship between autophagy dysfunction and the process of IBD. The progress of several autophagy regulators for intestinal epithelial cells and macrophages is highlighted (inflammasome inhibitors, intestinal flora regulators, and other signal regulators) in the current studies on IBD.

inflammatory bowel disease  /  autophagy  /  intestinal epithelial cell  /  macrophage  /  intestinal barrier
Wen-sheng YANG, Wei WU, Jing-lin WANG, Guang-fei WANG, Zhi-ping LI. Autophagy-regulated strategies in pre-clinical studies of inflammatory bowel disease[J]. Acta Pharmaceutica Sinica, 2023 , 58 (1) : 1 -8 . DOI: 10.16438/j.0513-4870.2022-0836
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Article Info
doi: 10.16438/j.0513-4870.2022-0836
  • Receive Date：2022-07-07
  • Online Date：2025-11-21
  • Published：2023-01-12
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  • Received：2022-07-07
  • Revised：2022-08-05
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Affiliations
    1. Department of Pharmacy, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China
    2. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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