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Four new sesquiterpenoids from the roots of Atractylodes macrocephala
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Gang-gang ZHOU1, Jia-jia LIU1, Ji-qiong WANG1, Hui LIU2, Zhi-Hua LIAO3, Guo-wei WANG1, Min CHEN1, *, Fan-cheng MENG1, *
Acta Pharmaceutica Sinica | 2025, 60(1) : 179 - 184
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Acta Pharmaceutica Sinica | 2025, 60(1): 179-184
• Original Articles •
Four new sesquiterpenoids from the roots of Atractylodes macrocephala
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Gang-gang ZHOU1, Jia-jia LIU1, Ji-qiong WANG1, Hui LIU2, Zhi-Hua LIAO3, Guo-wei WANG1, Min CHEN1, *, Fan-cheng MENG1, *
Affiliations
  • 1. Southwest University College of Pharmaceutical Science, Chongqing 400715, China
  • 2. Foshan University School of Medicine, Foshan 528099, China
  • 3. School of Life Sciences, Southwest University, Chongqing 400715, China
Published: 2025-01-12 doi: 10.16438/j.0513-4870.2024-0668
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The chemical constituents in dried roots of Atractylodes macrocephala were investigated in this study. Through utilizing normal-phase silica gel and ODS column chromatography, TLC, and semi-preparative HPLC, 4 new sesquiterpenoids were purified from the ethyl acetate extract of A. macrocephala. By various spectroscopic techniques, such as 1D and 2D NMR, HR-ESI-MS, IR, UV, and CD, their structures were identified as atractylmacron A (1), 9β-hydroxyasterolide (2), atractylenolide H (3), atractylenolide J (4). Compound 1 possesses a rare 6/7 bicyclic skeleton.

Atractylodes macrocephala  /  chemical constituent  /  sesquiterpenoid  /  extraction and isolation  /  structural elucidation
Gang-gang ZHOU, Jia-jia LIU, Ji-qiong WANG, Hui LIU, Zhi-Hua LIAO, Guo-wei WANG, Min CHEN, Fan-cheng MENG. Four new sesquiterpenoids from the roots of Atractylodes macrocephala[J]. Acta Pharmaceutica Sinica, 2025 , 60 (1) : 179 -184 . DOI: 10.16438/j.0513-4870.2024-0668
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Year 2025 volume 60 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2024-0668
  • Receive Date：2024-07-15
  • Online Date：2025-11-07
  • Published：2025-01-12
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History
  • Received：2024-07-15
  • Revised：2024-09-30
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Affiliations
    1. Southwest University College of Pharmaceutical Science, Chongqing 400715, China
    2. Foshan University School of Medicine, Foshan 528099, China
    3. School of Life Sciences, Southwest University, Chongqing 400715, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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