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Progress on antisense oligonucleotide in the field of antibacterial therapy
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Jia LI1, Xiao-lu HAN1, 2, Shi-yu SONG3, Jin-tao LIN1, Zhi-qiang TANG1, 4, Zeng-ming WANG1, Liang XU1, *, Ai-ping ZHENG1, *
Acta Pharmaceutica Sinica | 2025, 60(2) : 337 - 347
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Acta Pharmaceutica Sinica | 2025, 60(2): 337-347
• Reviews •
Progress on antisense oligonucleotide in the field of antibacterial therapy
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Jia LI1, Xiao-lu HAN1, 2, Shi-yu SONG3, Jin-tao LIN1, Zhi-qiang TANG1, 4, Zeng-ming WANG1, Liang XU1, *, Ai-ping ZHENG1, *
Affiliations
  • 1. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
  • 2. Troops 32104 of People's Liberation Army of China, Alashanmeng 735400, China
  • 3. Chongqing Medical University, Chongqing 400016, China
  • 4. College of Pharmacy, Yanbian University, Yanji 133002, China
Published: 2025-02-12 doi: 10.16438/j.0513-4870.2024-0607
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With the widespread use of antibiotics, drug-resistant bacterial infections have become a significant threat to human health. Finding new antibacterial strategies that can effectively control drug-resistant bacterial infections has become an urgent task. Unlike small molecule drugs that target bacterial proteins, antisense oligonucleotide (ASO) can target genes related to bacterial resistance, pathogenesis, growth, reproduction and biofilm formation. By regulating the expression of these genes, ASO can inhibit or kill bacteria, providing a novel approach for the development of antibacterial drugs. To overcome the challenge of delivering antisense oligonucleotide into bacterial cells, various drug delivery systems have been applied in this field, including cellpenetrating peptides, lipid nanoparticles and inorganic nanoparticles, which have injected new momentum into the development of antisense oligonucleotide in the antibacterial realm. This review summarizes the current development of small nucleic acid drugs, the antibacterial mechanisms, targets, sequences and delivery vectors of antisense oligonucleotide, providing a reference for the research and development of antisense oligonucleotide in the treatment of bacterial infections.

nucleic acid drug  /  antisense oligonucleotide  /  antibacterial  /  drug delivery  /  gene therapy
Jia LI, Xiao-lu HAN, Shi-yu SONG, Jin-tao LIN, Zhi-qiang TANG, Zeng-ming WANG, Liang XU, Ai-ping ZHENG. Progress on antisense oligonucleotide in the field of antibacterial therapy[J]. Acta Pharmaceutica Sinica, 2025 , 60 (2) : 337 -347 . DOI: 10.16438/j.0513-4870.2024-0607
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doi: 10.16438/j.0513-4870.2024-0607
  • Receive Date：2024-07-01
  • Online Date：2025-11-07
  • Published：2025-02-12
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History
  • Received：2024-07-01
  • Revised：2024-11-20
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Affiliations
    1. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
    2. Troops 32104 of People's Liberation Army of China, Alashanmeng 735400, China
    3. Chongqing Medical University, Chongqing 400016, China
    4. College of Pharmacy, Yanbian University, Yanji 133002, China
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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