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Research progress of nano drug delivery system based on metalpolyphenol network for the diagnosis and treatment of inflammatory diseases
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Meng-jie ZHAO1, Xia-li ZHU1, Yi-jing LI1, Zi-ang WANG1, Yun-long ZHAO1, Gao-jian WEI1, Yu CHEN1, Sheng-nan HUANG2, 3, *
Acta Pharmaceutica Sinica | 2025, 60(2) : 323 - 336
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Acta Pharmaceutica Sinica | 2025, 60(2): 323-336
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Research progress of nano drug delivery system based on metalpolyphenol network for the diagnosis and treatment of inflammatory diseases
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Meng-jie ZHAO1, Xia-li ZHU1, Yi-jing LI1, Zi-ang WANG1, Yun-long ZHAO1, Gao-jian WEI1, Yu CHEN1, Sheng-nan HUANG2, 3, *
Affiliations
  • 1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
Published: 2025-02-12 doi: 10.16438/j.0513-4870.2024-0572
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Inflammatory diseases (IDs) are a general term of diseases characterized by chronic inflammation as the primary pathogenetic mechanism, which seriously affect the quality of patient′s life and cause significant social and medical burden. Current drugs for IDs include nonsteroidal anti-inflammatory drugs, corticosteroids, immunomodulators, biologics, and antioxidants, but these drugs may cause gastrointestinal side effects, induce or worsen infections, and cause non-response or intolerance. Given the outstanding performance of metal polyphenol network (MPN) in the fields of drug delivery, biomedical imaging, and catalytic therapy, its application in the diagnosis and treatment of IDs has attracted much attention and significant progress has been made. In this paper, we first provide an overview of the types of IDs and their generating mechanisms, then sort out and summarize the different forms of MPN in recent years, and finally discuss in detail the characteristics of MPN and their latest research progress in the diagnosis and treatment of IDs. This research may provide useful references for scientific research and clinical practice in the related fields.

inflammatory disease  /  metal polyphenol network  /  nano drug delivery system  /  diagnosis  /  treatment
Meng-jie ZHAO, Xia-li ZHU, Yi-jing LI, Zi-ang WANG, Yun-long ZHAO, Gao-jian WEI, Yu CHEN, Sheng-nan HUANG. Research progress of nano drug delivery system based on metalpolyphenol network for the diagnosis and treatment of inflammatory diseases[J]. Acta Pharmaceutica Sinica, 2025 , 60 (2) : 323 -336 . DOI: 10.16438/j.0513-4870.2024-0572
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doi: 10.16438/j.0513-4870.2024-0572
  • Receive Date：2024-06-19
  • Online Date：2025-11-07
  • Published：2025-02-12
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  • Received：2024-06-19
  • Revised：2024-08-07
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Affiliations
    1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
    3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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