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Five new triterpenoid saponins from the kernels of Momordica cochinchinensis
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Ru DING1, Jia-qi WANG1, Yi-yang LUO1, Yong-long HAN2, Xiao-bo LI1, *, Meng-yue WANG1, *
Acta Pharmaceutica Sinica | 2025, 60(2) : 442 - 448
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Acta Pharmaceutica Sinica | 2025, 60(2): 442-448
• Original Articles •
Five new triterpenoid saponins from the kernels of Momordica cochinchinensis
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Ru DING1, Jia-qi WANG1, Yi-yang LUO1, Yong-long HAN2, Xiao-bo LI1, *, Meng-yue WANG1, *
Affiliations
  • 1. School of Pharmaceutical Science, Shanghai Jiao Tong University, Shanghai 200240, China
  • 2. Department of Pharmacy, Shanghai Sixth People's Hospital, Shanghai 200233, China
Published: 2025-02-12 doi: 10.16438/j.0513-4870.2024-1013
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Five saponins were isolated from the kernels of Momordica cochinchinensis, by macroporous resin, silica gel, ODS column chromatography, and semi preparative HPLC. Based on MS and NMR analysis, combining with alkaline hydrolysis and acid hydrolysis, their structures were identified as: gypsogenin-3-O-{β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonosyl}-28-O-β-D-xylopyranosyl (1→3)-[β-D-xylopyranosyl (1→4)]-α-L-rhamnopyranosyl (1→2)-β-D-fucopyranoside (1), quillaic acid-3-O-{β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonosyl}-28-O-β-D-xylopyranosyl (1→3)-[β-D-xylopyranosyl (1→4)]-α-L-rhamnopyranosyl (1→2)-β-D-fucopyranoside (2), gypsogenin-3-O-β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonoside sodium (3), quillaic acid-3-O-β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonoside sodium (4), 18α-quillaic acid-3-O-β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonoside (5). Compounds 1-5 were new compounds, and named as mubezhisides A, B, C, D, E, respectively. They all could obviously inhibited the growth of Candida albicans, C. parapsilosis, and C. tropicalis.

Momordica cochinchinensis  /  kernel  /  triterpenoid saponin  /  mubezhiside  /  antifungal activity  /  Candida
Ru DING, Jia-qi WANG, Yi-yang LUO, Yong-long HAN, Xiao-bo LI, Meng-yue WANG. Five new triterpenoid saponins from the kernels of Momordica cochinchinensis[J]. Acta Pharmaceutica Sinica, 2025 , 60 (2) : 442 -448 . DOI: 10.16438/j.0513-4870.2024-1013
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Year 2025 volume 60 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2024-1013
  • Receive Date：2024-10-18
  • Online Date：2025-11-07
  • Published：2025-02-12
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History
  • Received：2024-10-18
  • Revised：2024-12-10
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Affiliations
    1. School of Pharmaceutical Science, Shanghai Jiao Tong University, Shanghai 200240, China
    2. Department of Pharmacy, Shanghai Sixth People's Hospital, Shanghai 200233, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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