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Research progress in the application of microneedles drug delivery system in infectious wounds
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Chao-xiong WU, Qing-yu YU, Chen-lu HUANG, Lin-hua ZHANG, Dun-wan ZHU*
Acta Pharmaceutica Sinica | 2025, 60(3) : 711 - 720
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Acta Pharmaceutica Sinica | 2025, 60(3): 711-720
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Research progress in the application of microneedles drug delivery system in infectious wounds
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Chao-xiong WU, Qing-yu YU, Chen-lu HUANG, Lin-hua ZHANG, Dun-wan ZHU*
Affiliations
  • Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin 300192, China
Published: 2025-03-12 doi: 10.16438/j.0513-4870.2024-1010
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Wound healing caused by skin trauma and chronic diseases is often complicated and difficult due to infection. In such cases, the wound healing process is not only a long and continuous one, but also prone to scar repair. Conventional dressings and antibiotic treatments suffer from issues such as low drug delivery efficiency and systemic toxicity. In recent years, microneedle technology has been widely used to reduce infection and promote wound healing. Microneedles can not only penetrate the skin stratum corneum and biofilm to enhance drug delivery efficiency and reduce drug side effects, but also can be combined with a variety of materials to achieve multiple treatments and monitoring of wounds. This article will discuss the healing mechanism of infected wounds, the classification of microneedles, and their applications in the treatment of infected wounds.

microneedle  /  wound  /  antibacterial  /  anti-inflammation  /  infection
Chao-xiong WU, Qing-yu YU, Chen-lu HUANG, Lin-hua ZHANG, Dun-wan ZHU. Research progress in the application of microneedles drug delivery system in infectious wounds[J]. Acta Pharmaceutica Sinica, 2025 , 60 (3) : 711 -720 . DOI: 10.16438/j.0513-4870.2024-1010
Year 2025 volume 60 Issue 3
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doi: 10.16438/j.0513-4870.2024-1010
  • Receive Date:2024-10-17
  • Online Date:2025-11-06
  • Published:2025-03-12
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  • Received:2024-10-17
  • Revised:2024-12-16
Affiliations
    Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin 300192, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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