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The applications of cyclic peptides in pharmaceutical sciences
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En-qi CHEN1, Hui-zhong MA1, Yu-bi WANG1, Yu-han ZHANG1, Ran SONG1, Yu-feng LIU1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(5) : 1390 - 1406
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Acta Pharmaceutica Sinica | 2025, 60(5): 1390-1406
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The applications of cyclic peptides in pharmaceutical sciences
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En-qi CHEN1, Hui-zhong MA1, Yu-bi WANG1, Yu-han ZHANG1, Ran SONG1, Yu-feng LIU1, 2, *
Affiliations
  • 1. School of Pharmacy, Liaoning University, Shenyang 110036, China
  • 2. Liaoning Natural Product Pharmaceutical Engineering Technology Research Center, Shenyang 110036, China
Published: 2025-05-12 doi: 10.16438/j.0513-4870.2024-1028
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In recent years, a large number of peptide compounds have been obtained from natural sources or synthesized chemically, which have attracted significant interest due to their high biological activity and low side effects. However, linear peptides encounter many challenges in the field of drug development because they are easily broken down by enzymes and do not pass through cell membranes well. Cyclic peptides, on the other hand, have a stable structure, strong binding to targets, and lower toxicity. They combine the advantages of natural peptides and small molecule drugs in terms of biological activity and drug metabolism, addressing the shortcomings of linear peptides and becoming increasingly important in drug research. This article focuses on the development history of cyclic peptides, discusses the sources, acquisition methods, and specific applications in the field of pharmacology in recent years, and prospects for their future development potential, aiming to provide a theoretical and practical basis for the clinical application of cyclic peptides.

cyclic peptide  /  development  /  cyclization  /  applications in pharmaceutical science
En-qi CHEN, Hui-zhong MA, Yu-bi WANG, Yu-han ZHANG, Ran SONG, Yu-feng LIU. The applications of cyclic peptides in pharmaceutical sciences[J]. Acta Pharmaceutica Sinica, 2025 , 60 (5) : 1390 -1406 . DOI: 10.16438/j.0513-4870.2024-1028
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Article Info
doi: 10.16438/j.0513-4870.2024-1028
  • Receive Date：2024-10-22
  • Online Date：2025-10-29
  • Published：2025-05-12
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History
  • Received：2024-10-22
  • Revised：2025-02-20
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    1. School of Pharmacy, Liaoning University, Shenyang 110036, China
    2. Liaoning Natural Product Pharmaceutical Engineering Technology Research Center, Shenyang 110036, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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