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Research progress on the role of immune cells in pulmonary fibrosis
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Guang-li SHENG1, Ya-ru SUN1, Hong-liang DONG2, Jian GAO2, *, Xuan ZHANG1, *
Acta Pharmaceutica Sinica | 2025, 60(5) : 1344 - 1353
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Acta Pharmaceutica Sinica | 2025, 60(5): 1344-1353
• Reviews •
Research progress on the role of immune cells in pulmonary fibrosis
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Guang-li SHENG1, Ya-ru SUN1, Hong-liang DONG2, Jian GAO2, *, Xuan ZHANG1, *
Affiliations
  • 1. School of Pharmacy, Kunming Medical University, Kunming 650500, China
  • 2. Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Published: 2025-05-12 doi: 10.16438/j.0513-4870.2024-0891
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Pulmonary fibrosis (PF) is a lung disease with a very poor prognosis that seriously affects the quality of life of patients and is characterized by scarring and thickening of the tissue surrounding the alveolar walls, ultimately leading to respiratory failure. Currently, the Food and Drug Administration (FDA) approved drugs for the treatment of PF include pirfenidone and nidazanib, however, these two drugs can only delay the progression of the disease but cannot achieve the reversal of PF, and their clinical application is limited due to high price and multiple adverse effects. The pathogenesis of PF has not been fully elucidated, and studies have demonstrated that aberrant immune cell activation and regulation play an important role in PF. This review aims to discuss the role of immune cell activation and regulation in PF in recent years. The aim of this review is to discuss recent advances in the study of the role of immune cells in the process of PF, with the aim of providing theoretical guidance for the development of novel immunotherapies.

pulmonary fibrosis  /  immune cell  /  mechanism of action  /  immune activation  /  macrophage
Guang-li SHENG, Ya-ru SUN, Hong-liang DONG, Jian GAO, Xuan ZHANG. Research progress on the role of immune cells in pulmonary fibrosis[J]. Acta Pharmaceutica Sinica, 2025 , 60 (5) : 1344 -1353 . DOI: 10.16438/j.0513-4870.2024-0891
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Year 2025 volume 60 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2024-0891
  • Receive Date：2024-09-11
  • Online Date：2025-10-29
  • Published：2025-05-12
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History
  • Received：2024-09-11
  • Revised：2024-12-19
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Affiliations
    1. School of Pharmacy, Kunming Medical University, Kunming 650500, China
    2. Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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