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Research progress and new approaches in the development of human cytomegalovirus vaccines
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Yuan-yuan WANG1, Shi-hao CUI2, Yu-chao GU3, *
Acta Pharmaceutica Sinica | 2025, 60(4) : 895 - 902
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Acta Pharmaceutica Sinica | 2025, 60(4): 895-902
• Reviews •
Research progress and new approaches in the development of human cytomegalovirus vaccines
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Yuan-yuan WANG1, Shi-hao CUI2, Yu-chao GU3, *
Affiliations
  • 1School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • 2Jianda Biopharmaceutical (Nanjing) Co., Ltd., Nanjing 210031, China
  • 3College of Biological Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
Published: 2025-04-12 doi: 10.16438/j.0513-4870.2024-1137
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Human cytomegalovirus (HCMV) infection poses significant morbidity and/or mortality risks for individuals with compromised immune systems, rendering it one of the most prevalent congenital infections worldwide. The pursuit of HCMV vaccines has spanned over five decades, with clinical trials primarily focusing on various vaccine candidates, including live attenuated vaccines, viral vectored vaccines, subunit vaccines, peptide vaccines, DNA vaccines, RNA vaccines, and viral-like particle vaccines, usually accompanied by the use of adjuvants. Although the development of vaccines against HCMV is being actively promoted, there are still numerous obstacles and challenges persisting in the research process, due to unique pathogenic characteristics and infection mechanisms of HCMV. Based on the summarized research progress, this article analyzes and discusses the faced challenges and potential approaches to provide valuable insights and guidance for the exploration and development of new vaccines candidates, and ultimately achieve prevention and control of HCMV infection.

human cytomegalovirus  /  infection mechanism  /  antigen  /  immunosuppression  /  vaccine
Yuan-yuan WANG, Shi-hao CUI, Yu-chao GU. Research progress and new approaches in the development of human cytomegalovirus vaccines[J]. Acta Pharmaceutica Sinica, 2025 , 60 (4) : 895 -902 . DOI: 10.16438/j.0513-4870.2024-1137
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Year 2025 volume 60 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2024-1137
  • Receive Date：2024-11-16
  • Online Date：2025-10-29
  • Published：2025-04-12
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History
  • Received：2024-11-16
  • Revised：2025-01-06
Affiliations
    1School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
    2Jianda Biopharmaceutical (Nanjing) Co., Ltd., Nanjing 210031, China
    3College of Biological Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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